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Synthetic pathway of glycosphingolipids. Main series of glycosphingolipids were indicated in italic. Main glycosyltransferases involved in the synthesis of individual structures were also indicated in italic. Deleted structures in the individual knockout of glycosyltransferases were shown by enclosing with squares. Representative mono- and disialyl gangliosides known to suppress or enhance malignant properties of cancer cells were marked blue or reddish backgrounds, respectively.
