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. 2019 Sep;8(5):1672–1679. doi: 10.21037/tcr.2019.08.01

Figure 4.

Figure 4

Cells proliferation in A549 cells after transfections. After transfections, elevated circ-ITCH expression level in circ-ITCH(+) group and reduced circ-ITCH expression level in circ-ITCH(−) group were discovered at 24 h (A). Cells proliferation was reduced in circ-ITCH(+) group and increased in circ-ITCH(−) group at 72 h (B). T-test was used to compare the level of circ-ITCH expression between two groups. NC(+): A549 transfected with blank plasmids; circ-ITCH(+): A549 transfected with circ-ITCH overexpression plasmids; NC(−): A549 transfected with blank shRNA plasmids; circ-ITCH(−): A549 transfected with circ-ITCH shRNA plasmids. *, P<0.05; **, P<0.01; ***, P<0.001; #, P<0.05; ##, P<0.01. Circ-ITCH, circular RNA-itchy E3 ubiquitin protein ligase.