Table 3. Univariate and multivariate analyses of prognostic factors in ESCC.
| Variable | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| P | HR (95% CI) | P | HR (95% CI) | ||
| Gender | 0.019 | 0.755, (0.597, 0.955) | 0.221 | 0.860 (0.675, 1.095) | |
| Age | 0.024 | 1.311 (1.037, 1.658) | 0.082 | 1.236 (0.973, 1.568) | |
| Surgical approach | 0.840 | 0.977 (0.780, 1.224) | |||
| Open | Ref | ||||
| Minimally | 0.507 | 1.250 (0.646, 2.418) | |||
| Hybrid | 0.684 | 0.904 (0.558, 1.467) | |||
| T stage | 0.000 | 1.681 (1.529, 1.849) | 0.000 | 1.464 (1.321, 1.622) | |
| T1 | Ref | Ref | |||
| T2 | 0.000 | 1.998 (1.386, 2.880) | 0.006 | 1.685 (1.165, 2.436) | |
| T3 | 0.000 | 3.323 (2.429, 4.547) | 0.000 | 2.347 (1.694, 3.252) | |
| T4 | 0.000 | 5.073 (3.632, 7.084) | 0.000 | 3.257 (2.289, 4.635) | |
| N stage | 0.000 | 1.529 (1.458, 1.738) | 0.000 | 1.206 (1.094, 1.330) | |
| N0 | Ref | Ref | |||
| N1 | 0.000 | 2.017 (1.645, 2.473) | 0.004 | 1.362 (1.101, 1.685) | |
| N2 | 0.000 | 2.756 (2.183, 3.479) | 0.000 | 1.571 (1.228, 2.009) | |
| N3 | 0.000 | 3.356 (2.315, 4.865) | 0.032 | 1.531 (1.037, 2.262) | |
| M stage | 0.003 | 3.451 (1.537, 7.751) | 0.669 | 1.196 (0.526, 2.721) | |
| Differentiation | 0.000 | 1.285 (1.122, 1.471) | 0.422 | 1.063 (0.916, 1.232) | |
| High | Ref | Ref | |||
| Moderate | 0.011 | 1.408 (1.083, 1.830) | 0.782 | 0.968 (0.722, 1.215) | |
| Low | 0.000 | 1.706 (1.279, 2.277) | 0.212 | 1.170 (0.914, 1.499) | |
| Location | 0.874 | 0.988 (0.852, 1.145) | |||
| Upper | Ref | ||||
| Middle | 0.573 | 0.913 (0.666, 1.252) | |||
| Lower | 0.680 | 0.932 (0.669, 1.300) | |||
| Vascular invasion | 0.017 | 1.548 (1.082, 2.214) | 0.018 | 1.552 (1.079, 2.234) | |
| TNM stage | 0.000 | 2.219 (1.944, 2.532) | 0.000 | 1.878 (1.644, 2.145) | |
| I | Ref | Ref | |||
| II | 0.000 | 1.827 (1.318, 2.533) | 0.002 | 1.692 (1.220, 2.347) | |
| III | 0.000 | 4.343 (3.183, 5.926) | 0.000 | 3.343 (2.440, 4.580) | |
| IV | 0.000 | 11.909 (5.588, 25.380) | 0.000 | 5.910 (2.749, 12.707) | |
| Recurrence | 0.000 | 3.919 (3.287, 4.672) | 0.000 | 3.212 (2.676, 3.855) | |
| LMR | 0.000 | 0.709 (0.549, 0.846) | 0.018 | 0.786 (0.645, 0.959) | |
| NMR | 0.405 | 0.897 (0.696, 1.158) | |||
| NLR | 0.000 | 1.382 (1.159, 1.649) | 0.028 | 1.247 (1.024, 1.519) | |
ESCC, esophageal squamous cell carcinoma; LMR, lymphocyte-monocyte ratio; NLR, neutrophil-lymphocyte ratio; NMR, neutrophil-monocyte ratio; T stage, tumor stage; N stage, node stage; M stage, metastasis stage; TNM stage, tumor node metastasis stage; HR, hazard ratio; 95% CI, 95% confidence interval; Ref, reference.