Table 3. Cox proportional hazard regression model analysis (OS).
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | ||
| Age | 1 | – | |||||
| >50 vs. ≤50 | 0.439 | 0.165–1.12 | 0.789 | – | – | – | |
| Stage | 1 | 1 | |||||
| T1/2 vs. T3/4 | 5.428 | 2.213–12.361 | 0.0000* | 4.845 | 2.109–11.789 | 0.000* | |
| Grade | 1 | – | |||||
| I/II vs. III/IV | 0.318 | 0.167–0.109 | 0.026* | – | – | – | |
| Gender | 1 | – | |||||
| Male vs. female | 2.058 | 0.998–4.225 | 0.055 | – | – | – | |
| HBV | 1 | – | |||||
| Negative vs. positive | 1.295 | 0.601–2.712 | 0.613 | – | – | – | |
| AFP (ng/mL) | 1 | – | |||||
| ≤400 vs. >400 | 0.612 | 0.237–1.776 | 0.315 | – | – | – | |
| Liver cirrhosis | 1 | – | |||||
| No vs. yes | 1.150 | 0.483–2.789 | 0.926 | – | – | – | |
| SRC-1 | 1 | 1 | |||||
| Negative vs. positive | 3.257 | 1.326–9.128 | 0.0056* | 3.167 | 1.246–7.935 | 0.020* | |
| Twist1 | 1 | 1 | |||||
| Negative vs. positive | 2.578 | 1.254–7.457 | 0.031* | 3.481 | 1.465–10.274 | 0.0061* | |
| SRC-1/Twist1 | 1 | – | |||||
| All others vs. SRC-1+/Twist1+ | 3.621 | 1.673–8.191 | 0.0027* | 1.679 | 1.052–3.349 | 0.004* | |
*, statistically significant. OS, overall survival; HBV, hepatitis B virus; AFP, alpha-fetoprotein; CI, confidence interval.