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. 2021 Jun;10(6):2747–2754. doi: 10.21037/tcr-21-283

Table 2. Prognostic factors for the OS and DFS in patients with secondary OSCC.

Parameters No. of case 5-year OS (%) Log-rank Cox regression 3-year DFS (%) Log-rank Cox regression
Univariate Multivariate Univariate
P HR (95% CI) P HR (95% CI) P P HR (95% CI) P
Age 0.151 0.582 (0.274–1.234) 0.151 0.934 0.972 (0.485–1.947) 0.936
   ≥60 years 25 49.0 35.6
   <60 years 23 30.4 36.3
Gender 0.519 0.783 (0.371–1.652) 0.519 0.903 0.957 (0.467–1.961) 0.905
   Male 32 45.8 39.3
   Female 16 27.3 30.0
Drinker 0.378 1.886 (0.447–7.962) 0.388 0.774 1.162 (0.407–3.314) 0.779
   Yes 7 68.6 38.1
   No 41 36.4 35.3
Smoker 0.149 2.138 (0.740–6.183) 0.161 0.650 1.209 (0.523–2.798) 0.657
   Yes 12 62.9 38.9
   No 36 32.9 34.6
Clinical stage 0.494 1.345 (0.571–3.167) 0.497 0.929 1.035 (0.478–2.238) 0.931
   I + II 13 50.8 38.5
   III + IV 35 35.0 34.8
Margin status 0.001 4.033 (1.643–9.899) 0.002 3.976 (1.596–9.904) 0.003 0.001 3.538 (1.608–7.782) 0.002
   Positive 9 22.2 11.1
   Negative 39 44.9 41.5
Lymph node 0.865 1.071 (0.483–2.377) 0.866 0.514 1.277 (0.603–2.705) 0.524
   N+ 14 39.7 22.2
   N0 34 39.4 40.4
ENE 0.050 2.765 (0.954–8.012) 0.061 2.622 (0.891–7.721) 0.080 0.410 1.626 (0.491–5.387) 0.426
   + 4 40.8 37.0
   − 44 25.0 25.0
Differentiation 0.501 1.434 (0.497–4.141) 0.505 0.814 0.869 (0.265–2.857) 0.818
   Poor 5 40.0 40.0
   Well & moderate 43 39.4 35.2
Treatment mode 0.907 0.948 (0.383–2.345) 0.908 0.878 0.937 (0.405–2.170) 0.880
   Surgical only 37 39.3 39.3
   Comprehensive 11 40.0 40.0

OS, overall survival; DFS, disease-free survival; HR, hazard ratio; ENE, extra-nodal extension.