Table 4.
Demographic and clinic characteristics of patients and genetic information of 38 MDR-MTB clustered isolates.
| Drug resistance gene mutation | |||||||||
| ID of cluster | Age | Sex | Previous treatment | MIRU-VNTR | Beijing | rpoB | katG | inhA | fabG |
| 1 | 45 | M | New | 243333352543425563342833 | Yes | Ser450Leu | – | – | −15C>T |
| 1 | 40 | M | New | 243333352543425563342833 | Yes | His445Tyr | Ser315Thr | – | – |
| 1 | 22 | M | Retreatment | 243333352543425563342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 2 | 60 | M | Retreatment | 243333352543425563342633 | Yes | Ser450Leu | Ser315Thr | – | – |
| 2 | 60 | M | New | 243333352543425563342633 | Yes | Ser450Leu | Ser315Thr | – | – |
| 2 | 78 | M | New | 243333352543425563342633 | Yes | Ser450Leu | Ser315Thr | – | – |
| 3 | 68 | M | Retreatment | 243333362643425563342833 | Yes | His445Leu | Ser315Thr | – | – |
| 3 | 59 | M | Retreatment | 243333362643425563342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 3 | 14 | F | New | 243333362643425563342833 | Yes | Ser450Leu | – | – | – |
| 4 | 61 | M | New | 243333352643425563342833 | Yes | Asp435Val | Ser315Thr | – | −15C>T |
| 4 | 48 | M | New | 243333352643425563342833 | Yes | Ser450Leu | Trp191Arg | – | −15C>T |
| 4 | 32 | F | Retreatment | 243333352643425563342833 | Yes | Ser450Leu | – | – | −15C>T |
| 4 | 61 | M | Retreatment | 243333352643425563342833 | Yes | Asp435Val | Ser315Thr | – | – |
| 4 | 22 | F | New | 243333352643425563342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 4 | 47 | M | New | 243333352643425563342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 5 | 28 | F | Retreatment | 243333352643425563342843 | Yes | Ser450Leu | Ser315Thr | – | – |
| 5 | 51 | M | Retreatment | 243333352643425563342843 | Yes | Ser450Leu | Ser315Thr | – | – |
| 5 | 88 | F | New | 243333352643425563342843 | Yes | Ser450Leu | – | – | – |
| 6 | 51 | M | Retreatment | 243333352643425163342833 | Yes | Ser450Leu | – | – | – |
| 6 | 61 | M | New | 243333352643425163342833 | Yes | His445Leu | Ser315Thr | – | – |
| 7 | 61 | M | Retreatment | 233332352643425153342833 | Yes | Ser450Leu | – | – | – |
| 7 | 63 | M | Retreatment | 233332352643425153342833 | Yes | Ser450Leu | – | – | −15C>T |
| 7 | 45 | M | New | 233332352643425153342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 7 | 37 | M | Retreatment | 233332352643425153342833 | Yes | Asp435Val | Ser315Thr | – | – |
| 7 | 22 | M | New | 233332352643425153342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 7 | 59 | M | New | 233332352643425153342833 | Yes | Asp435Tyr | – | – | – |
| 7 | 41 | F | New | 233332352643425153342833 | Yes | Asn437Asp, Asp435Val | Ser315Thr | – | −15C>T |
| 8 | 29 | M | New | 233333352543425153342833 | Yes | Ser450Leu | – | – | −15C>T |
| 8 | 77 | M | Retreatment | 233333352543425153342833 | Yes | Ser450Leu | – | – | – |
| 9 | 36 | F | Retreatment | 233333352643425573342833 | Yes | Ser450Leu | Ser315Thr | – | −8C>T |
| 9 | 30 | F | New | 233333352643425573342833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 10 | 26 | M | New | 243333342533425563343833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 10 | 35 | F | New | 243333342533425563343833 | Yes | His445Tyr | – | – | −15C>T |
| 10 | 73 | M | Retreatment | 243333342533425563343833 | Yes | Ser450Leu | Ser315Asn | – | – |
| 10 | 72 | M | New | 243333342533425563343833 | Yes | Ser450Leu | Ser315Thr | – | – |
| 10 | 35 | M | Retreatment | 243333342533425563343833 | Yes | His445Tyr | Ser315Thr | – | – |
| 11 | 78 | M | New | 143432312643215532330832 | No | Ser450Leu | Ser315Thr | – | – |
| 11 | 55 | M | New | 143432312643215532330832 | No | Ser450Leu | Ser315Thr | – | – |
MDR-MTB = multidrug-resistant Mycobacterium tuberculosis, MIRU-VNTR = mycobacterial interspersed repetitive unit-variable number tandem repeat typing.