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. 2021 Jul;10(7):3538–3547. doi: 10.21037/tcr-21-536

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2021 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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The proportion of changed CD3− immune cell clusters (B and NK cells) in PBMCs after coculture with A549 cells irradiated at various doses with the FFF technique at a high-dose rate and a conventional dose rate. (A) Proportion of NK cells in PBMCs after coculture with A549 cells irradiated at 1,000 MU/min. (B) Proportion of NK cells in PBMCs after cocultures with A549 cells irradiated at 400 MU/min. (C) Proportion of B cells in PBMCs after coculture with A549 cells irradiated at 1,000 MU/min. (D) Proportion of B cells in PBMCs after coculture with A549 cells irradiated at 400 MU/min. *P value <0.05. FFF, flattening filter-free; PBMC, peripheral blood mononuclear cell; NK, natural killer.