Table 3. Odds ratios and 95% CI on breast cancer risk regarding distribution of abdominal fat, pre- and post-menopausal status in all subjects.
| Factors | Tertile (range) | No. (%) of participants | Crude | Multivariate* | |||||
|---|---|---|---|---|---|---|---|---|---|
| Case | Control | Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | ||||
| Abdominal fat ratio | |||||||||
| Pre-menopause | Reference (<26.87) | 66 (50.8) | 33 (33.7) | ||||||
| 1st vs. 2nd (26.88–33.43) | 24 (18.5) | 33 (33.7) | 0.41 (0.21–0.80) | 0.05 | 0.47 (0.23–0.96) | 0.06 | |||
| 1st vs. 3rd (>33.44) | 40 (30.8) | 32 (32.7) | 0.60 (0.32–1.12) | 0.31 | 0.88 (0.46–1.67) | 0.6 | |||
| Post-menopause | Reference (<29.88) | 27 (26.0) | 38 (33.6) | ||||||
| 1st vs. 2nd (29.89–37.19) | 25 (24.0) | 38 (33.6) | 0.89 (0.43–1.80) | 0.22 | 0.89 (0.38–1.70) | 0.25 | |||
| 1st vs. 3rd (≥37.20) | 52 (50.0) | 37 (32.7) | 1.94 (1.01–3.71) | 0.03 | 1.53 (0.73–2.88) | 0.04 | |||
| Abdominal total fat (mm2) | |||||||||
| Pre-menopause | Reference (<16,803) | 54 (41.5) | 33 (33.7) | ||||||
| 1st vs. 2nd (16,804–24,329) | 46 (35.4) | 33 (33.7) | 0.87 (0.46–1.62) | 0.49 | 0.84 (0.43–1.61) | 0.42 | |||
| 1st vs. 3rd (≥24,330) | 30 (23.1) | 32 (32.7) | 0.55 (0.28–1.07) | 0.07 | 0.60 (0.32–1.23) | 0.05 | |||
| Post-menopause | Reference (<19,875) | 16 (15.4) | 38 (33.6) | ||||||
| 1st vs. 2nd (19,876–30,013) | 47 (45.2) | 38 (33.6) | 2.87 (1.39–5.93) | 0.01 | 2.54 (1.18–5.34) | 0.01 | |||
| 1st vs. 3rd (≥30,014) | 41 (39.4) | 37 (32.7) | 2.56 (1.23–5.35) | 0.02 | 1.88 (0.83–3.98) | 0.02 | |||
| Abdominal visceral fat (mm2) | |||||||||
| Pre-menopause | Reference (<4,198) | 51 (39.2) | 33 (33.7) | ||||||
| 1st vs. 2nd (4,199–6,998) | 40 (30.8) | 33 (33.7) | 0.78 (0.41–1.48) | 0.36 | 0.83 (0.42–1.63) | 0.32 | |||
| 1st vs. 3rd (≥6,999) | 39 (30.0) | 32 (32.7) | 0.78 (0.41–1.49) | 0.38 | 0.98 (0.49–1.93) | 0.36 | |||
| Post-menopause | Reference (<6,016) | 17 (16.3) | 38 (33.6) | ||||||
| 1st vs. 2nd (6,017–10,615) | 43 (41.3) | 38 (33.6) | 2.47 (1.20–5.08) | 0.01 | 2.19 (1.00–4.34) | 0.04 | |||
| 1st vs. 3rd (≥10,616) | 44 (42.3) | 37 (32.7) | 2.59 (1.26–5.34) | 0.01 | 1.84 (0.81–3.76) | 0.03 | |||
| Abdominal subcutaneous fat (mm2) | |||||||||
| Pre-menopause | Reference (<11,951) | 60 (46.2) | 33 (33.7) | ||||||
| 1st vs. 2nd (11,952–16,630) | 40 (30.8) | 33 (33.7) | 0.66 (0.35–1.24) | 0.43 | 0.63 (0.34–1.21) | 0.39 | |||
| 1st vs. 3rd (≥16,632) | 30 (23.1) | 32 (32.7) | 0.51 (0.26–0.99) | 0.32 | 0.53 (0.22–1.04) | 0.29 | |||
| Post-menopause | Reference (<13,507) | 26 (25.0) | 38 (33.6) | ||||||
| 1st vs. 2nd (13,508–18,089) | 37 (35.6) | 38 (33.6) | 1.38 (0.70–2.72) | 0.09 | 1.32 (0.65–2.72) | 0.11 | |||
| 1st vs. 3rd (≥18,090) | 41 (39.4) | 37 (32.7) | 1.56 (0.80–3.08) | 0.07 | 1.33 (0.69–2.70) | 0.13 | |||
*, odds ratio adjusted for age (year), menstruation (post-menopausal; pre-menopausal), family history (positive family history; negative family history), and age at menarche (12 year or less; 13 year; 14 year; 15 year or older).