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. 2021 Nov;10(11):4958–4972. doi: 10.21037/tcr-21-919

Figure 1.

Figure 1

Cancer stem cells. (A) A model of cellular hierarchy within the tumor, with a self-perpetuating population of pluripotent cancer stem cells found on the top. (B) Various cancers encompass a subpopulation of DNA-internalizing cancer cells, referred to as TAMRA+ cancer stem cells (arrowheads): (I) sphere-forming cell line arising from human Epstein-Barr virus-induced lymphoma; (II) mouse Krebs-2 ascites; (III) a human lymphoma cell cluster. Cells (106) were incubated with 0.1 mkg TAMRA-labeled DNA fragment (human Alu repeat, about 500 bp) for 1 hour at room temperature in the dark.