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. 2019 Sep;8(5):2192–2204. doi: 10.21037/tcr.2019.08.23

Figure 2.

Figure 2

LncRNAs affect epithelial-mesenchymal transition in CRC cells CHRF inhibits the expression of miR-489 and provokes TWIST1 to promote EMT; H19 inhibits miR-138 and miR-200a then induces Vimentin, ZEB1, and ZEB2 to promote EMT; YAP1 induces lncMALAT1, which inhibits miR-126-5p and provokes ZEB1 to promote EMT; TGF-β induces lncATB, which inhibits miR-200s and provokes ZEB1 to facilitate EMT; EWSAT1promotes EMT by increasing snail1, snail1 and N-cadherin, and decreasing E-cadherin. XIST bind with miR-200b-3p, and increase the expression of the ZEB1 to promote EMT, at the same time, XIST bind with miR-137, and increase the expression of the EZH2 to promote EMT; HOTAIR promoted the EMT by decreasing E-cadherin and increasing vimentin and MMP9; AFAP1-AS1 encoding AFAP1 stimulate EMT; BANCR was upregulated and promoted EMT; TGF-β downregulate Linc01133 and inhibit EMT; cps1-it1reversed the EMT by inhibiting HIF-1a. LncRNAs, long non-coding RNAs; CRC, colorectal cancer.