Table 3. Univariate and multivariate Cox’s regression analyses for OS and DFS in colorectal cancer patients.

Variable	DFS					OS
	Univariate P	Multivariate				Univariate P	Multivariate
		HR	95% CI	P			HR	95% CI	P
Gender: male vs. female	0.904					0.427
Age: <65 vs. ≥65	0.116					0.101
Vascular invasion	0.065	1.610	0.795–3.259	0.186		0.007	1.950	0.935–4.064	0.075
Perineural invasion	0.867					0.385
Serum CEA: normal vs. elevated	0.208					0.049	1.735	0.937–3.214	0.080
Tumor location: right vs. left colon	0.954					0.695
Differentiation: well vs. poorly	0.135					0.193
T stage: T1, 2 vs. T3, 4	0.007					0.003
N stage: N0 vs. N1, 2	0.011					0.006
TNM: I, II vs. III, IV	0.001	2.102	1.302–3.392	0.002		0.000	2.356	1.315–4.222	0.004
Post-surgical chemotherapy: no vs. yes	0.164					0.399
RANBP9: low vs. high expression	0.017	0.580	0.356–0.946	0.029		0.061	0.553	0.309–0.989	0.046

DFS, disease free survival; OS, overall survival; CEA, carcinoembryonic antigen; TNM, tumor node metastasis; RANBP9, RAN-binding protein 9.