Figure 2.

The known functions and mechanisms of two special lung cancer lncRNAs, TUG1 and PANDAR, are demonstrated in this figure. Green lines stand for the molecular interaction specific for lung carcinoma, while red lines stand for the common pathways that mediate the action of TUG1 and PANDAR in other cancers. These two lncRNAs function as cancer inhibitors in lung carcinoma. The unique cancer-inhibiting functions of TUG1 and PANDAR are both mediated by RNA binding proteins, and regulated by p53 in lung cancer, while their p53-dependent anti-tumor mechanism has not been reported to be involved in other malignancies.