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. 2019 Nov;8(7):2636–2653. doi: 10.21037/tcr.2019.10.22

Table 1. Lung cancer-associated lncRNAs.

LncRNAs Alterations Lung cancer phenotypes Function in lung cancer References
AFAP1-AS1 Upregulated Invasion and metastasis Promoting (25)
AC006050.3-003 Upregulated Drug-resistance Promoting (26)
AK126698 Downregulated Drug-resistance Inhibiting (27)
BANCR Downregulated Invasion and metastasis Inhibiting (28,29)
ANRIL Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (30,31)
BCYRN1 Upregulated Invasion and metastasis Promoting (32)
CAR10 Upregulated Proliferation and apoptosis Promoting (33)
CCAT1 Upregulated Cancer initiation, proliferation and apoptosis, drug-resistance Promoting (34,35)
CCAT2 Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (36-38)
DLX6-AS1 Upregulated Unexplored Promoting (39)
DQ786227 Upregulated Cancer initiation Promoting (40)
GAS5 Downregulated Proliferation and apoptosis, drug-resistance Inhibiting (41-45)
GAS6-as1 Downregulated Unexplored Inhibiting (46)
GHSROS Upregulated Invasion and metastasis Promoting (47)
H19 Upregulated Cancer initiation, proliferation and apoptosis Promoting (48-54)
HMlincRNA717 Downregulated Unexplored Inhibiting (55)
HNF1A-AS1 Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (56)
HOTAIR Upregulated Cancer initiation, drug-resistance, proliferation and apoptosis, invasion and metastasis Promoting (57-64)
LINC01133 Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (65-67)
LINCRNA-p21 Downregulated Proliferation and apoptosis Inhibiting (13,68)
lnc-bc060912 Upregulated Proliferation and apoptosis Promoting (69)
loc728228 Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (70)
LUADT1 Upregulated Proliferation and apoptosis Promoting (71)
MALAT1 Upregulated Invasion and metastasis Promoting (72-80)
MEG3 Downregulated Cancer initiation, proliferation and apoptosis, drug-resistance Inhibiting (81-83)
LINC00115 Upregulated Unexplored Unexplored (84)
MIAT1 Upregulated Unexplored Unexplored (84)
MVIH Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (85)
NEAT1 Upregulated Proliferation and apoptosis, drug-resistance Promoting (86,87)
NKX2-1-AS1 Upregulated Proliferation and apoptosis Promoting (88)
PANDAR Downregulated Proliferation and apoptosis Inhibiting (89)
DRAIC Downregulated Invasion and metastasis Inhibiting (90)
PVT1 Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (91,92)
RGMB-AS1 Upregulated Proliferation and apoptosis, invasion and metastasis Promoting (93)
SCAL1 Upregulated Proliferation and apoptosis, anti-cytotoxic effect Promoting (94,95)
SOX2-OT Upregulated Proliferation and apoptosis Promoting (96)
SPRY4-IT1 Upregulated Invasion and metastasis Promoting (97)
TUG1 Downregulated Proliferation and apoptosis Inhibiting (98)
ZXF1 Upregulated Invasion and metastasis Promoting (99)
lncRNA-LET Downregulated Invasion and metastasis Inhibiting (100)
UCA1 Upregulated Drug-resistance Promoting (101)
XIST Upregulated Invasion and metastasis Promoting (102)