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Novel GBM subtyping based on TC-6 core regulons. (a) The workflow of TC-6 regulons-based subtyping of human GBMs. (b) Consensus clustering based on metagenes from core regulons identified three subgroups. (c) t-SNE analysis of the three subtypes. (d-e) Kaplan–Meier survival analyses of overall survival in GBMs with C3 and non-C3 subtypes using the TCGA mRNA cohort (d) and CGGA RNA-seq cohort (e). **, p < 0.01; *, p < 0.05.
