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. 2022 Jan 26;11(1):2030020. doi: 10.1080/2162402X.2022.2030020

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — C3 subtype predicts poor immunotherapeutic response. (a) Kaplan–Meier analyses of patient overall survival of anti-PD-1-treated GBMs with different subtypes (GSE121810). (b) GSEA analysis of enriched immune modules with statistical significance in C3 subtype relative to the non-C3 subtypes. The column plot (left panel) showed the normalized enrichment score of each module. Concordance index (C-index) was presented for the indicated characteristic immune module (right panel). Predictive power (high to low) was indicated as bar color (red to blue). (c) GSEA plots of the representative enriched functional modules in C3 subtype. NES, Normalized enrichment score.