Table 5. Multivariate analyses of factors affecting overall survival and cancer-specific survival in secondary liver cancer patients with the specific primary sites.
| Variable | Primary site | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Colorectum | Pancreas | Lung | |||||||||||||||
| Overall survival | Cancer-specific survival | Overall survival | Cancer-specific survival | Overall survival | Cancer-specific survival | ||||||||||||
| HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | ||||||
| Age at diagnosis, years | |||||||||||||||||
| <40 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| 40–59 | 1.102 (0.994–1.221) |
0.064 | 1.097 (0.987–1.219) |
0.085 | 1.725 (1.446–2.058) |
<0.001 | 1.52 (1.266–1.825) |
<0.001 | 1.543 (1.266–1.882) |
<0.001 | 1.253 (1.021–1.538) |
0.031 | |||||
| 60–79 | 1.702 (1.538–1.883) |
<0.001 | 1.478 (1.332–1.64) |
<0.001 | 2.381 (2–2.836) | <0.001 | 1.947 (1.624–2.334) |
<0.001 | 1.924 (1.58–2.344) |
<0.001 | 1.559 (1.272–1.91) |
<0.001 | |||||
| ≥80 | 3.384 (3.042–3.764) |
<0.001 | 2.473 (2.216–2.759) |
<0.001 | 3.971 (3.324–4.742) |
<0.001 | 3.102 (2.579–3.731) |
<0.001 | 2.735 (2.24–3.34) |
<0.001 | 2.117 (1.723–2.601) |
<0.001 | |||||
| Gender | |||||||||||||||||
| Male | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| Female | 1.024 (0.987–1.061) |
0.202 | 1.037 (0.999–1.077) |
0.058 | 0.966 (0.934–0.998) |
0.038 | 0.955 (0.923–0.988) |
0.008 | 0.871 (0.846–0.896) |
<0.001 | 0.898 (0.872–0.924) |
<0.001 | |||||
| Race | |||||||||||||||||
| White | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| Black | 1.234 (1.175–1.296) |
0.064 | 1.077 (1.023–1.133) |
0.005 | 1.138 (1.085–1.194) |
<0.001 | 1.121 (1.067–1.177) |
<0.001 | 1.01 (0.965–1.057) |
0.656 | 1.017 (0.97–1.067) |
0.473 | |||||
| Others | 0.956 (0.898–1.018) |
<0.001 | 0.962 (0.901–1.027) |
0.246 | 0.976 (0.918–1.038) |
0.437 | 1.007 (0.945–1.072) |
0.838 | 0.745 (0.701–0.792) |
<0.001 | 0.822 (0.772–0.876) |
<0.001 | |||||
| Tumor size, cm | |||||||||||||||||
| <2 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| 2–4 | 0.911 (0.807–1.028) |
0.132 | 0.942 (0.829–1.07) |
0.356 | 1.011 (0.927–1.103) |
0.799 | 0.993 (0.907–1.086) |
0.870 | 1.027 (0.969–1.088) |
0.373 | 1.017 (0.958–1.08) |
0.579 | |||||
| 5–9 | 1.08 (0.959–1.217) |
0.203 | 1.073 (0.947–1.217) |
0.267 | 1.101 (1.006–1.204) |
0.036 | 1.107 (1.009–1.214) |
0.032 | 1.14 (1.074–1.209) |
<0.001 | 1.097 (1.032–1.166) |
0.003 | |||||
| ≥10 | 1.275 (1.108–1.467) |
0.001 | 1.224 (1.057–1.418) |
0.007 | 1.113 (0.961–1.289) |
0.153 | 1.183 (1.017–1.377) |
0.029 | 1.217 (1.118–1.325) |
<0.001 | 1.178 (1.079–1.287) |
<0.001 | |||||
| Grade | |||||||||||||||||
| Grade I | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| Grade II | 1.041 (0.939–1.154) |
0.443 | 1.031 (0.927–1.147) |
0.575 | 2.279 (1.934–2.685) |
<0.001 | 1.551 (1.309–1.838) |
<0.001 | 1.273 (1.064–1.524) |
0.008 | 1.071 (0.889–1.29) |
0.471 | |||||
| Grade III | 1.645 (1.476–1.834) |
<0.001 | 1.459 (1.304–1.633) |
<0.001 | 3.089 (2.636–3.62) |
<0.001 | 1.899 (1.611–2.237) |
<0.001 | 1.703 (1.439–2.015) |
<0.001 | 1.35 (1.133–1.609) |
0.001 | |||||
| Grade IV | 1.926 (1.667–2.226) |
<0.001 | 1.512 (1.3–1.758) |
<0.001 | 3.059 (2.425–3.858) |
<0.001 | 2.026 (1.598–2.568) |
<0.001 | 1.697 (1.423–2.023) |
<0.001 | 1.257 (1.046–1.51) |
0.015 | |||||
| N-stage | |||||||||||||||||
| Node negative | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| Node positive | 1.618 (1.493–1.754) |
<0.001 | 1.189 (1.092–1.294) | <0.001 | 1.225 (1.01–1.486) |
0.039 | 1.169 (0.959–1.425) |
0.122 | 1.134 (0.945–1.359) |
0.176 | 0.977 (0.811–1.178) |
0.808 | |||||
| Additional metastasis | |||||||||||||||||
| None | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||||||||
| Bone | 1.557 (1.406–1.726) |
<0.001 | 1.402 (1.262–1.557) |
<0.001 | 1.181 (1.08–1.291) |
<0.001 | 1.158 (1.058–1.269) |
0.002 | 1.079 (1.042–1.117) |
<0.001 | 1.055 (1.017–1.094) |
0.004 | |||||
| Brain | 1.795 (1.334–2.416) |
<0.001 | 1.219 (0.899–1.652) |
0.202 | 1.634 (1.161–2.301) |
0.005 | 1.61 (1.137–2.279) |
0.007 | 1.144 (1.077–1.217) |
<0.001 | 1.115 (1.047–1.187) |
0.001 | |||||
| Lung | 1.24 (1.185–1.297) |
<0.001 | 1.117 (1.066–1.17) |
<0.001 | 1.302 (1.241–1.365) |
<0.001 | 1.234 (1.175–1.295) |
<0.001 | 1.134 (1.076–1.194) |
<0.001 | 1.102 (1.044–1.164) |
<0.001 | |||||
| Two or Three | 1.721 (1.562–1.896) |
<0.001 | 1.394 (1.263–1.54) |
<0.001 | 1.503 (1.362–1.658) |
<0.001 | 1.331 (1.202–1.473) |
<0.001 | 1.162 (1.11–1.216) |
<0.001 | 1.153 (1.101–1.208) |
<0.001 | |||||