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. 2019 Oct;8(6):2405–2415. doi: 10.21037/tcr.2019.09.54

Figure 3.

Figure 3

Infiltrating Treg cells triggered EMT in HCC cells. (A) mRNA expression of EMT-related molecules evaluated using RT-PCR assays. The expression levels of mesenchymal biomarkers, including N-cadherin, Vimentin, and fibronectin increased (*P<0.05 vs. NC). Protein expression levels of E-cadherin and Vimentin (B) and Twist (C) in Huh7 and MHCC97H cells evaluated using WB assays. The expression levels of E-cadherin decreased while the expression levels of Vimentin and Twist increased at the protein level when co-cultured with Treg cells.