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. 2019 Oct;8(6):2405–2415. doi: 10.21037/tcr.2019.09.54

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Infiltrating Treg cells secreted high levels of TGFβ1 and had high mRNA expression. Active TGFβ1 concentrations were detected by ELISA. mRNA expression levels of TGFβ1 and FoxP3 were detected by RT-PCR. Treg cells were obtained from the intratumoral environment and the peripheral blood of patients with HCC, and Treg cells from the peripheral blood of healthy donors were selected as control. (A) Treg cells exhibited the highest TGFβ1 mRNA expression levels compared with Tregs from the peripheral blood of healthy donors. Foxp3 mRNA expression levels showed no difference among the three groups. (B) Supernatant of infiltrating Treg cells contained significantly higher concentrations of TGFβ1 compared with those of Treg cells from the peripheral blood of healthy donors while no significant difference compared with intratumoral TGFβ1 (*P<0.01 vs. peripheral blood).