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HIF-1α knockdown decreases tumor volume and ANXA3 expression in nude xenograft tumor model. (A) Compared with flank control group the tumor volume was much smaller in HIF-1α siRNA group. (B) Immunohistochemistry analysis of ANXA3 and HIF-1α in the xenograft tumors from SW480 and SW620 colon cancer cells. Original magnification, ×200. HIF-1α, hypoxia-inducible factor 1-alpha; ANXA3, annexin A3.
