Table 5.
Alterations in the renal and liver function during the study
| Osveral® (Mean ± SD) |
Exjade® (Mean ± SD) |
P value | ||
|---|---|---|---|---|
| Creatinine (mg/dL) | Baseline | 0.78 ± 0.17 | 0.72 ± 0.12 | 0.1 |
| At the end of 2th month | 0.80 ± 0.18 | 0.74 ± 0.13 | 0.4 | |
| At the end of 4th month | 0.83 ± 0.16 | 0.79 ± 0.14 | 0.9 | |
| At the end of 6th month | 0.81 ± 0.15 | 0.76 ± 0.11 | 0.7 | |
|
Urinary protein
(mg/d) |
Baseline | 15.6 ± 22.6 | 17.8 ± 25.9 | 0.6 |
| At the end of 2th month | 17.6 ± 35.1 | 19.2 ± 38.9 | 0.9 | |
| At the end of 4th month | 10.7 ± 16.2 | 11.9 ± 7.3 | 0.7 | |
| At the end of 6th month | 8.3 ± 13.4 | 10.5 ± 22.3 | 0.3 | |
|
Urinary creatinine
(mg/dL) |
Baseline | 121.7 ± 124.2 | 159.2 ± 221.7 | 0.5 |
| At the end of 2th month | 123.9 ± 91.3 | 148.7 ± 239.1 | 0.2 | |
| At the end of 4th month | 83.5 ± 43.2 | 119.6 ± 221.2 | 0.4 | |
| At the end of 6th month | 95.5 ± 35.2 | 113.9 ± 147.3 | 0.5 | |
|
Alanine aminotransferase
(U/L) |
Baseline | 24.7 ± 11.7 | 25.3 ± 12.8 | 0.84 |
| At the end of 2th month | 25.4 ± 13.6 | 25.2 ± 16.7 | 0.97 | |
| At the end of 4th month | 23.4 ± 14.7 | 23.1 ± 10.4 | 0.89 | |
| At the end of 6th month | 24.7 ± 13.1 | 20.5 ± 10.2 | 0.13 | |
|
Aspartate
Aminotransferase (U/L) |
Baseline | 26.2 ± 18.3 | 21.1 ± 19.2 | 0.25 |
| At the end of 2th month | 28.5 ± 24.0 | 27.9±22.1 | 0.91 | |
| At the end of 4th month | 22.9 ± 19.3 | 23.4 ± 14.0 | 0.9 | |
| At the end of 6th month | 24.5 ± 15.1 | 19.8 ± 13.4 | 0.15 | |
mg/dL: milligrams per deciliter; mg/d: Milligrams per day; SD: Standard Deviation; U/L: Units per litre