Table 1.
Summary statistics for pharmacokinetic parameters of different formulations of sumatriptan (SS). SUMA1: SS solution after for IV injection, SUMA2: SS solution for nasal delivery, NL: nanoliposomes (NLs) containing SS for nasal delivery, CCL: Chitosan coated liposomes (CCLs) containing SS for nasal delivery
| Parameters | SUMA1 | SUMA2 | NL | CCL |
|---|---|---|---|---|
| AUC0- 240
(ng.min/ml) |
14860/8 | 1051/5 | 3478/8 | 5575/9 |
| AUC0-60
(ng.min/ml) |
10388/3 | 363/5 | 1220/8 | 2419/3 |
| AUC0- 90 (ng.min/ml) |
12058/8 | 544/0 | 1733/3 | 3234/3 |
| Cmax (ng/ml) | 234/0 | 6/4 | 17/7 | 30/8 |
| tmax b (min) | 15 | 90 | 90 | 60 |