Table 2.
Relative AUC0-240 Cmax and tmax and their confidence intervals of different nasal formulations of sumatriptan (SS). SUMA2: SS solution, NL: nanoliposomes (NLs) containing SS, CCL: Chitosan coated liposomes (CCLs) containing SS
|
Comparison of
Formulations |
Mean ratio AUC 0-240 | Mean ratio C max | Median differencet max (min) |
|---|---|---|---|
| (90% CI) | (90% CI) | (90% CI) | |
| CCL/ NL | 1.60 (1.13,2.12) |
1.75 (1.27,2.24) |
-30 (-27,-33) |
| CCL / SUMA2 | 5.30 (4.55,6.10) |
4.84 (4.30,5.38) |
-30 (-27,-33) |
| NL / SUMA2 | 3.31 (2.76,3.85) |
2.77 (2.19,3.37) |
0 (1,1) |