Table 1. The significantly differentially expressed metabolites between the treatment and control groups.
| No. | Name | VIP | Adj. P value | FC | Expressing trends |
|---|---|---|---|---|---|
| 1 | Isocitric acid | 1.1020 | 0.0084 | 1.8511 | Upregulated |
| 2 | 2-hydroxypentanoic acid | 1.7756 | 0.0003 | 1.5165 | Upregulated |
| 3 | N-acetylornithine | 1.8574 | 0.0001 | 1.4909 | Upregulated |
| 4 | Glutamine | 1.3846 | 0.0095 | 1.3616 | Upregulated |
| 5 | Trehalose-6-phosphate | 1.4970 | 0.0034 | 1.3413 | Upregulated |
| 6 | Uridine 5’-monophosphate | 1.4394 | 0.0034 | 1.2815 | Upregulated |
| 7 | O-phosphoserine | 1.5299 | 0.0017 | 1.2539 | Upregulated |
| 8 | Glycine | 1.6753 | 0.0011 | 1.2482 | Upregulated |
| 9 | 5-methoxytryptamine | 1.8584 | 0.0001 | 1.2411 | Upregulated |
| 10 | Glycyl proline | 1.4859 | 0.0056 | 1.2134 | Upregulated |
| 11 | Indoxyl sulfate | 1.2116 | 0.0364 | 1.2025 | Upregulated |
| 12 | 2-monoolein | 1.4132 | 0.0104 | 0.8297 | Downregulated |
| 13 | Gamma-aminobutyric acid | 1.6109 | 0.0020 | 0.8290 | Downregulated |
| 14 | Guanosine | 1.2399 | 0.0304 | 0.8132 | Downregulated |
| 15 | Oxalic acid | 1.2676 | 0.0329 | 0.8116 | Downregulated |
| 16 | N-acetyl-d-mannosamine | 1.0815 | 0.0485 | 0.8053 | Downregulated |
| 17 | 3-hydroxybenzoic acid | 1.6178 | 0.0019 | 0.8043 | Downregulated |
| 18 | Saccharopine | 1.3948 | 0.0113 | 0.8034 | Downregulated |
| 19 | Erythritol | 1.6087 | 0.0019 | 0.7953 | Downregulated |
| 20 | Phenylalanine | 1.3433 | 0.0129 | 0.7925 | Downregulated |
| 21 | Aspartic acid | 1.4731 | 0.0121 | 0.7918 | Downregulated |
| 22 | Digalacturonic acid | 1.5938 | 0.0020 | 0.7878 | Downregulated |
| 23 | Homoserine | 1.4031 | 0.0093 | 0.7867 | Downregulated |
| 24 | 3-(3-hydroxyphenyl)-3-hydroxypropionic acid | 1.3003 | 0.0134 | 0.7588 | Downregulated |
| 25 | Uracil | 1.4230 | 0.0206 | 0.7520 | Downregulated |
| 26 | Enolpyruvate | 1.6525 | 0.0020 | 0.7467 | Downregulated |
| 27 | Thymine | 1.8096 | 0.0003 | 0.7190 | Downregulated |
| 28 | Udp-glucuronic acid | 1.7496 | 0.0009 | 0.7153 | Downregulated |
| 29 | N-carbamoylaspartate | 1.7602 | 0.0007 | 0.6940 | Downregulated |
| 30 | Glutaric acid | 1.2701 | 0.0225 | 0.6697 | Downregulated |
| 31 | Galactonic acid | 1.6475 | 0.0009 | 0.6581 | Downregulated |
| 32 | Gluconic acid | 1.8046 | 0.0005 | 0.6292 | Downregulated |
| 33 | Hexaric acid | 1.7207 | 0.0021 | 0.5690 | Downregulated |
| 34 | Tagatose | 1.4755 | 0.0165 | 0.5530 | Downregulated |
| 35 | Dodecanol | 1.6834 | 0.0073 | 0.4421 | Downregulated |
| 36 | 4a-carbinolamine tetrahydrobiopterin | 1.6895 | 0.0087 | 0.3818 | Downregulated |