Table 2. The integrated enrichment pathway list.
| MetaboAnalyst pathway | Total | Hits | Raw P | Holm adjust | Impact |
|---|---|---|---|---|---|
| Drug metabolism—other enzymes | 70 | 18 | 0.0000 | 0.0033 | 0.3623 |
| Nitrogen metabolism | 10 | 6 | 0.0001 | 0.0077 | 0.3333 |
| Glutathione metabolism | 56 | 13 | 0.0014 | 0.1135 | 0.5091 |
| Alanine, aspartate, and glutamate metabolism | 61 | 12 | 0.0088 | 0.7151 | 0.7000 |
| Glyoxylate and dicarboxylate metabolism | 56 | 11 | 0.0121 | 0.9700 | 0.4727 |
| Mucin type O-glycan biosynthesis | 22 | 6 | 0.0127 | 0.9996 | 0.6191 |
| Glycerolipid metabolism | 35 | 8 | 0.0127 | 0.9996 | 0.6177 |
| Citrate cycle (TCA cycle) | 42 | 9 | 0.0129 | 0.9996 | 1.0732 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 11 | 4 | 0.0142 | 1.0000 | 2.0000 |
| Purine metabolism | 166 | 24 | 0.0167 | 1.0000 | 0.7818 |
| Pentose and glucuronate interconversions | 32 | 7 | 0.0245 | 1.0000 | 0.7742 |
| Ascorbate and aldarate metabolism | 13 | 4 | 0.0266 | 1.0000 | 0.6667 |
| Cysteine and methionine metabolism | 71 | 12 | 0.0282 | 1.0000 | 0.4857 |
| Lysine degradation | 49 | 9 | 0.0336 | 1.0000 | 0.4375 |
| Phenylalanine metabolism | 21 | 5 | 0.0393 | 1.0000 | 0.9500 |
| Glycolysis or gluconeogenesis | 61 | 10 | 0.0518 | 1.0000 | 0.6000 |
| Propanoate metabolism | 48 | 8 | 0.0718 | 1.0000 | 0.7021 |
| Fructose and mannose metabolism | 40 | 7 | 0.0721 | 1.0000 | 0.4615 |
| Sulfur metabolism | 18 | 4 | 0.0790 | 1.0000 | 0.3529 |
| Arginine biosynthesis | 27 | 5 | 0.0993 | 1.0000 | 0.3077 |
| beta-Alanine metabolism | 44 | 7 | 0.1084 | 1.0000 | 0.4651 |
| Pyruvate metabolism | 45 | 7 | 0.1187 | 1.0000 | 0.7273 |
| One carbon pool by folate | 31 | 5 | 0.1553 | 1.0000 | 0.9333 |
| N-Glycan biosynthesis | 77 | 10 | 0.1734 | 1.0000 | 0.2763 |
| Glycine, serine and threonine metabolism | 68 | 9 | 0.1758 | 1.0000 | 0.7164 |
| Amino sugar and nucleotide sugar metabolism | 79 | 10 | 0.1942 | 1.0000 | 0.5897 |
| Pyrimidine metabolism | 99 | 12 | 0.2047 | 1.0000 | 0.8163 |
| Caffeine metabolism | 19 | 3 | 0.2570 | 1.0000 | 0.5556 |
| Retinol metabolism | 47 | 6 | 0.2688 | 1.0000 | 0.3044 |
| Pentose phosphate pathway | 47 | 6 | 0.2688 | 1.0000 | 0.9130 |
| Butanoate metabolism | 29 | 4 | 0.2814 | 1.0000 | 0.4643 |
| Ether lipid metabolism | 39 | 5 | 0.2945 | 1.0000 | 0.2632 |
| Arginine and proline metabolism | 78 | 9 | 0.2979 | 1.0000 | 0.4416 |
| Vitamin B6 metabolism | 21 | 3 | 0.3098 | 1.0000 | 1.1000 |
| Neomycin, kanamycin and gentamicin biosynthesis | 4 | 1 | 0.3235 | 1.0000 | 0.6667 |
| Folate biosynthesis | 61 | 7 | 0.3380 | 1.0000 | 0.2833 |
| Histidine metabolism | 32 | 4 | 0.3470 | 1.0000 | 0.2258 |
| Nicotinate and nicotinamide metabolism | 42 | 5 | 0.3517 | 1.0000 | 0.2683 |
| Porphyrin and chlorophyll metabolism | 53 | 6 | 0.3708 | 1.0000 | 0.2500 |
| Starch and sucrose metabolism | 43 | 5 | 0.3709 | 1.0000 | 0.4524 |
| Tryptophan metabolism | 84 | 9 | 0.3795 | 1.0000 | 0.3615 |
| Aminoacyl-tRNA biosynthesis | 74 | 8 | 0.3826 | 1.0000 | 0.1918 |
| Valine, leucine and isoleucine degradation | 88 | 9 | 0.4350 | 1.0000 | 0.4483 |
| Taurine and hypotaurine metabolism | 16 | 2 | 0.4468 | 1.0000 | 0.4000 |
| Inositol phosphate metabolism | 69 | 7 | 0.4647 | 1.0000 | 0.3677 |
| Galactose metabolism | 51 | 5 | 0.5217 | 1.0000 | 0.3600 |
| Drug metabolism—cytochrome P450 | 98 | 9 | 0.5697 | 1.0000 | 0.1134 |
| Riboflavin metabolism | 9 | 1 | 0.5854 | 1.0000 | 0.2500 |
| Fatty acid degradation | 102 | 9 | 0.6198 | 1.0000 | 1.3663 |
| D-Glutamine and D-glutamate metabolism | 10 | 1 | 0.6241 | 1.0000 | 0.1111 |
| Arachidonic acid metabolism | 81 | 7 | 0.6404 | 1.0000 | 0.2750 |
| Phosphatidylinositol signaling system | 74 | 6 | 0.7002 | 1.0000 | 0.4521 |
| Glycerophospholipid metabolism | 86 | 7 | 0.7030 | 1.0000 | 0.3059 |
| Fatty acid elongation | 75 | 6 | 0.7128 | 1.0000 | 0.6351 |
| Thiamine metabolism | 14 | 1 | 0.7461 | 1.0000 | 0.1539 |
| Steroid biosynthesis | 82 | 6 | 0.7903 | 1.0000 | 0.2222 |
| Metabolism of xenobiotics by cytochrome P450 | 145 | 11 | 0.8090 | 1.0000 | 0.3264 |
| Ubiquinone and other terpenoid-quinone biosynthesis | 17 | 1 | 0.8110 | 1.0000 | 0.2500 |
| Glycosphingolipid biosynthesis—ganglio series | 47 | 3 | 0.8280 | 1.0000 | 0.4348 |
| Glycosaminoglycan biosynthesis—chondroitin sulfate/ dermatan sulfate |
18 | 1 | 0.8287 | 1.0000 | 0.1177 |
| Pantothenate and CoA biosynthesis | 34 | 2 | 0.8397 | 1.0000 | 0.0909 |
| Terpenoid backbone biosynthesis | 36 | 2 | 0.8624 | 1.0000 | 0.1714 |
| alpha-Linolenic acid metabolism | 22 | 1 | 0.8845 | 1.0000 | 0.2857 |
| Primary bile acid biosynthesis | 92 | 5 | 0.9408 | 1.0000 | 0.4176 |
| Mannose type O-glycan biosynthesis | 30 | 1 | 0.9476 | 1.0000 | 0.0690 |
| Glycosphingolipid biosynthesis—globo and isoglobo series | 31 | 1 | 0.9525 | 1.0000 | 0.1333 |
| Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 31 | 1 | 0.9525 | 1.0000 | 0.2000 |
| Selenocompound metabolism | 35 | 1 | 0.9680 | 1.0000 | 0.0588 |
| Various types of N-glycan biosynthesis | 36 | 1 | 0.9711 | 1.0000 | 0.2857 |
| Glycosaminoglycan degradation | 44 | 1 | 0.9869 | 1.0000 | 0.1395 |
| Tyrosine metabolism | 88 | 3 | 0.9915 | 1.0000 | 0.2299 |
| Glycosphingolipid biosynthesis—lacto and neolacto series | 121 | 4 | 0.9975 | 1.0000 | 0.3333 |
| Fatty acid biosynthesis | 129 | 2 | 1.0000 | 1.0000 | 0.0469 |
| Steroid hormone biosynthesis | 199 | 5 | 1.0000 | 1.0000 | 0.2121 |