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Targeted inhibition of tumor cell proliferation by LHRH-a/CPT-11/PLGA nanometer microspheres. (A) CPT-11 inhibit the proliferation of ovarian cancer cell A2780/DDP (a cisplatin-resistant A2780 cell line). (B) LHRH-a/CPT-11/PLGA target A2780/DDP cells. (C) inhibition effects of treatments on proliferation of A2780/DDP cells. LHRH-a, luteinizing hormone releasing hormone analogue; CPT-11, irinotecan HCl trihydrate; PLGA, poly lactic-co-glycolic acid. *, P<0.05; **, P<0.01.
