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. 2021 Apr;10(4):1732–1743. doi: 10.21037/tcr-20-3171

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2021 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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LHRH-a/CPT-11/PLGA nanometer microspheres promote apoptosis of ovarian cancer cells. (A) Cell phase distribution of A2780/DDP cells (a cisplatin-resistant A2780 cell line) in the treatment by FCM (Flow cytometry). (B) mRNA level of Bcl-2/caspase3, and MMP2. (C,D) Protein level of Bcl-2/caspase3, and MMP2. In Figure 3C, 1, 2, 3, 4, 5, 1, 2, 3, 4, 5, 6, 7, 8 and 9 represent Con, CPT-11, CPT-11 + US (focused ultrasound), PLGA + H₂O, PLGA + H₂O + US, CPT-11/PLGA, CPT-11/PLGA + US, LHRH-α/CPT-11/PLGA, LHRH-α/CPT-11/PLGA + US. LHRH-a, luteinizing hormone releasing hormone analogue; CPT-11, irinotecan HCl trihydrate; PLGA, poly lactic-co-glycolic acid. *, P<0.05; **, P<0.01; ***, P<0.001.