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. 2021 Apr;10(4):1732–1743. doi: 10.21037/tcr-20-3171

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2021 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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LHRH-a/CPT-11/PLGA nanoparticles targeted inhibit tumor growth. (A) Subcutaneous xenotransplantation tumor model of human ovarian tumor in nude mice. (B) LHRH-a/CPT-11/PLGA target xenograft tumor (×800). (C) Growth curve of transplanted tumor in nude mice of each treatment group. (D) Weight of transplanted tumor in each group after treatment. LHRH-a, luteinizing hormone releasing hormone analogue; CPT-11, irinotecan HCl trihydrate; PLGA, poly lactic-co-glycolic acid. **, P<0.01; ***, P<0.001.