Table 3. Multivariate Cox regression model analysis for OS and CSS in nomogram cohort.
| Characteristics | Overall survival (OS) | Cancer-specific survival (CSS) | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Marital status | |||||
| Married | 1 (reference) | 1 (reference) | |||
| Single | 1.276 (0.950–1.713) | 0.105 | 1.178 (0.839–1.654) | 0.345 | |
| Unknown | 0.720 (0.387–1.337) | 0.298 | 0.561 (0.247–1.279) | 0.169 | |
| Primary site | Not selected | ||||
| Trigone of bladder | 1 (reference) | ||||
| Dome of bladder | 1.218 (0.528–2.810) | 0.645 | |||
| Lateral wall of bladder | 1.249 (0.621–2.516) | 0.533 | |||
| Anterior wall of bladder | 2.049 (0.632–6.647) | 0.232 | |||
| Posterior wall of bladder | 1.290 (0.610–2.727) | 0.505 | |||
| Bladder neck | 0.954 (0.372–2.446) | 0.922 | |||
| Ureteric orifice | 0.767 (0.094–6.245) | 0.804 | |||
| Urachus | 0.518 (0.172–1.558) | 0.242 | |||
| Overlapping lesion of bladder | 1.096 (0.570–2.107) | 0.785 | |||
| Bladder, NOS | 1.113 (0.613–2.020) | 0.725 | |||
| Grade | Not selected | ||||
| II | 1 (reference) | ||||
| III | 5.963 (1.211–29.368) | 0.028 | |||
| IV | 5.220 (1.040–26.210) | 0.045 | |||
| Unknown | 4.485 (0.881–22.833) | 0.071 | |||
| T stage | |||||
| Tis | 0.479 (0.063–3.660) | 0.478 | 0.001 (0.001–2.307) | 0.951 | |
| T1 | 1 (reference) | 1 (reference) | |||
| T2 | 1.358 (0.865–2.130) | 0.183 | 2.082 (1.134–3.822) | 0.018 | |
| T3 | 3.479 (1.998–6.059) | <0.001 | 5.566 (2.718–11.398) | <0.001 | |
| T4 | 2.871 (1.742–4.732) | <0.001 | 4.322 (2.233–8.366) | <0.001 | |
| Unknown | 0.704 (0.365–1.357) | 0.295 | 0.781 (0.302–2.020) | 0.611 | |
| N stage | |||||
| N0 | 1 (reference) | 1 (reference) | |||
| N1 | 1.187 (0.659–2.138) | 0.569 | 1.069 (0.535–2.139) | 0.849 | |
| N2 | 1.623 (0.979–2.691) | 0.061 | 1.873 (1.043–3.362) | 0.036 | |
| N3 | 1.004 (0.224–4.512) | 0.995 | 0.931 (0.119–7.263) | 0.946 | |
| Unknown | 0.714 (0.332–1.536) | 0.388 | 0.882 (0.343–2.270) | 0.794 | |
| M stage | |||||
| M0 | 1 (reference) | 1 (reference) | |||
| M1 | 1.931 (1.355–2.752) | <0.001 | 2.528 (1.661–3.848) | <0.001 | |
| Unknown | 0.852 (0.397–1.825) | 0.680 | 0.945 (0.313–2.854) | 0.921 | |
| Surgery | |||||
| No surgery | 1 (reference) | 1 (reference) | |||
| TURBT | 0.656 (0.424–1.014) | 0.058 | 1.119 (0.627–1.998) | 0.703 | |
| Partial cystectomy | 0.239 (0.115–0.497) | <0.001 | 0.273 (0.104–0.716) | 0.008 | |
| Radical cystectomy | 0.351 (0.209–0.588) | <0.001 | 0.536 (0.277–1.034) | 0.063 | |
| Other | 0.673 (0.381–1.189) | 0.173 | 0.984 (0.468–2.072) | 0.967 | |
| Radiation | Not selected | ||||
| No/unknown | 1 (reference) | ||||
| Yes | 1.096 (0.762–1.576) | 0.621 | |||
| Size (cm) | |||||
| ≤5.5 | 1 (reference) | 1 (reference) | |||
| >5.5 | 2.188 (1.398–3.424) | 0.001 | 2.378 (1.419–3.987) | 0.001 | |
| Unknown | 1.359 (0.978–1.890) | 0.068 | 1.322 (0.885–1.976) | 0.173 | |
| LNR | |||||
| No LN removed | 1 (reference) | 1 (reference) | |||
| More than one LN removed | – | – | |||
| LNR =0 | 0.366 (0.222–0.603) | <0.001 | 0.401 (0.224–0.719) | 0.002 | |
| ≤0.90 | 0.577 (0.361–0.922) | 0.021 | 0.498 (0.287–0.862) | 0.013 | |
| >0.90 | 0.849 (0.411–1.757) | 0.660 | 0.814 (0.349–1.896) | 0.633 | |
| Unknown | 0.482 (0.250–0.930) | 0.029 | 0.437 (0.192–0.993) | 0.048 | |
OS, overall survival; CSS, cancer-specific survival; HR, hazard ratio; CI, confidence interval; NOS, not otherwise specified; TURBT, transurethral resection of bladder tumor; LNR, lymph node ratio; LN, lymph node.