Table 1. Clinicopathological features of patients with diffuse large B cell lymphoma (DLBCL) stratified by body mass index (BMI).
| Variables | BMI, kg/m2 | P | |
|---|---|---|---|
| <27 (N=70) | ≥27 (N=15) | ||
| Age in years; mean ± SD | 65.1±16.9 | 55.2±12.0 | 0.034* |
| Males (%) | 41 (58.6) | 9 (60.0) | 0.919 |
| Performance status 0-1a; n (%) | 53 (75.7) | 13 (86.7) | 0.503 |
| LDHb level in U/L; mean ± SD | 245±253 | 416±500 | 0.232 |
| LDH level higher than normal (%) | 32 (47.8) | 10 (71.4) | 0.145 |
| β2-microglobulin, ng/mL; mean ± SD | 3,170±2,099 | 2,882±1,998 | 0.676 |
| Albumin, g/dL; mean ± SD | 3.4±0.8 | 3.6±0.7 | 0.285 |
| White cell count, ×109/L; mean ± SD | 7.7±3.0 | 6.3±2.1 | 0.088 |
| Hemoglobin, g/dL; mean ± SD | 11.7±1.9 | 12.8±2.8 | 0.150 |
| Platelet count, ×109/L; mean ± SD | 248±103 | 176±78 | 0.013* |
| IPIc score; mean ± SD | 2.22±1.39 | 2.13±1.51 | 0.823 |
| NCCN IPId score; mean ± SD | 3.51±1.88 | 3.47±1.81 | 0.939 |
| NCCN IPI high-intermediate & high risk; n (%) | 30 (44.8) | 8 (53.3) | 0.548 |
| Extranodal involvemente; n (%) | 35 (50.0) | 6 (40.0) | 0.482 |
| Cell of origin; n (%) | 0.122 | ||
| Germinal center B-cell like | 23 (37.7) | 2 (14.3) | |
| Non-germinal center B-cell | 38 (62.3) | 12 (85.7) | |
| MYC expression on IHCf stain; n (%) | 0.157 | ||
| Lowg | 62 (92.5) | 12 (80.0) | |
| Highg | 5 (7.5) | 3 (20.0) | |
| BCL2 expression on IHCf stain; n (%) | 0.005* | ||
| Lowh | 60 (89.6) | 9 (60.0) | |
| Highh | 7 (10.4) | 6 (40.0) | |
| BCL2 and MYC expression on IHCf stain; n (%) | 0.013* | ||
| BCL2low and MYClow | 54 (83.1) | 8 (53.3) | |
| BCL2high and/or MYChigh | 11 (16.9) | 7 (46.7) | |
a, ECOG performance status; b, LDH: lactate dehydrogenase; c, IPI: international prognostic index; d, NCCN-IPI: National Comprehensive Cancer Network International Prognostic Index; e, extranodal involvement of either BM, CNS, GI/liver, or lung; f, IHC stain: immunohistochemical stain; g, MYC expression: low: positive stain in <40% of cells; high: positive stain in ≥40% of cells; h, BCL2 expression: low: positive stain in <50% of cells; high: positive stain in ≥50% of cells. *, P value with significance.