Table 3. Common DEGs in the four most significant co-expression modules.
| Gene symbol | Dataset A | Dataset B | Dataset C | Dataset D | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| logFC | FDR | logFC | FDR | logFC | FDR | logFC | FDR | ||||
| Up-regulated | |||||||||||
| PYCR1 | 1.0834 | 2.60E-34 | 1.2966 | 2.01E-26 | 2.7821 | 4.05E-07 | 3.7387 | 9.68E-93 | |||
| CEACAM1 | 1.1290 | 7.28E-18 | 1.2744 | 7.37E-11 | 1.2071 | 1.90E-02 | 2.0955 | 2.63E-30 | |||
| ABCC3 | 1.3676 | 3.89E-22 | 1.9165 | 1.23E-19 | 3.7939 | 7.01E-09 | 2.5686 | 1.13E-37 | |||
| GOLM1 | 1.8824 | 7.93E-36 | 2.0276 | 8.61E-29 | 1.8870 | 4.45E-07 | 2.6754 | 4.03E-65 | |||
| HMGB3 | 2.1441 | 1.80E-36 | 1.7898 | 3.38E-13 | 1.9850 | 5.23E-04 | 3.5250 | 6.97E-48 | |||
| Down-regulated | |||||||||||
| SFTPC | 3.7846 | 8.10E-26 | 3.1933 | 6.72E-11 | 2.7964 | 5.01E-04 | 4.7077 | 9.03E-69 | |||
| FCN3 | 3.6158 | 1.00E-46 | 3.4480 | 4.02E-20 | 3.8986 | 9.14E-06 | 4.4931 | 3.91E-172 | |||
| TMEM100 | 3.5293 | 1.35E-41 | 3.6015 | 7.46E-18 | 3.9073 | 6.85E-09 | 4.3314 | 6.7E-141 | |||
| ABCA8 | 2.9376 | 7.81E-50 | 2.8246 | 2.07E-16 | 1.3704 | 2.67E-05 | 2.8318 | 1.23E-71 | |||
| CDH5 | 2.5828 | 1.01E-51 | 2.2366 | 7.80E-24 | 2.2076 | 2.85E-08 | 2.5234 | 4.06E-148 | |||
| GPM6A | 2.5467 | 3.4E-47 | 3.9236 | 2.82E-28 | 2.5505 | 3.51E-08 | 4.4338 | 9.26E-122 | |||
| EDNRB | 2.5449 | 9.55E-50 | 2.9911 | 4.45E-22 | 2.6127 | 6.85E-09 | 3.4758 | 1.75E-177 | |||
| GRK5 | 2.4935 | 2.23E-57 | 1.8852 | 2.82E-13 | 2.0877 | 2.73E-08 | 2.4636 | 2.62E-128 | |||
| TEK | 2.4787 | 1.72E-52 | 2.6268 | 3.02E-24 | 2.6799 | 2.85E-08 | 3.2279 | 6.82E-191 | |||
| CLDN18 | 2.4480 | 9.25E-32 | 3.2886 | 9.02E-14 | 2.2100 | 1.33E-03 | 3.5131 | 2.38E-38 | |||
| CA4 | 2.3105 | 9.1E-46 | 3.2181 | 2.02E-31 | 3.5226 | 3.35E-08 | 4.3314 | 2.42E-104 | |||
| TGFBR3 | 2.2710 | 4.24E-42 | 2.1643 | 1.94E-16 | 2.0791 | 1.06E-08 | 2.5536 | 6.25E-89 | |||
| LDB2 | 2.2329 | 2.04E-45 | 2.1822 | 3.70E-21 | 1.9013 | 1.88E-09 | 2.5873 | 8.98E-170 | |||
| CAV2 | 2.1706 | 1.36E-21 | 2.1045 | 2.90E-12 | 1.7610 | 1.53E-07 | 2.3153 | 1.51E-70 | |||
| EMP2 | 2.0621 | 3.99E-47 | 1.8399 | 9.91E-18 | 1.6546 | 7.72E-07 | 2.7098 | 4.00E-179 | |||
| VIPR1 | 2.0389 | 4.11E-37 | 1.9417 | 2.10E-15 | 2.6302 | 7.84E-10 | 3.2094 | 3.43E-127 | |||
| RAMP3 | 2.0118 | 1.71E-38 | 2.0534 | 1.66E-21 | 2.8286 | 7.72E-08 | 3.1995 | 5.78E-185 | |||
| GIMAP6 | 1.9154 | 8.16E-34 | 1.9864 | 1.40E-17 | 1.7776 | 1.18E-06 | 2.0685 | 2.62E-91 | |||
| DOCK4 | 1.8372 | 1.05E-30 | 1.4940 | 3.12E-20 | 1.2694 | 5.15E-07 | 1.5397 | 1.59E-59 | |||
| RAMP2 | 1.8250 | 1.01E-45 | 1.7628 | 2.60E-18 | 2.6198 | 2.92E-07 | 2.8586 | 1.83E-166 | |||
| RASIP1 | 1.8037 | 2.46E-45 | 2.0014 | 1.30E-28 | 2.1561 | 2.23E-08 | 2.2819 | 2.09E-101 | |||
| EMCN | 1.7935 | 1.17E-42 | 2.5049 | 3.43E-17 | 1.7784 | 7.21E-05 | 2.7228 | 1.43E-114 | |||
| SLC6A4 | 1.7909 | 1.87E-26 | 2.9093 | 1.14E-17 | 4.5929 | 7.01E-09 | 6.1370 | 9.64E-174 | |||
| IL33 | 1.7537 | 8.30E-29 | 2.0729 | 1.04E-12 | 1.5444 | 3.11E-05 | 2.0778 | 4.94E-41 | |||
| ERG | 1.7476 | 5.85E-40 | 1.4934 | 9.67E-14 | 2.0968 | 1.26E-05 | 2.1248 | 3.21E-115 | |||
| ADRB2 | 1.6150 | 2.42E-38 | 1.9791 | 6.43E-20 | 1.4662 | 1.3E-04 | 3.0541 | 1.69E-128 | |||
| ANXA3 | 1.5754 | 1.37E-17 | 1.7950 | 1.01E-10 | 1.4992 | 2.27E-04 | 1.8378 | 2.18E-41 | |||
| ITM2A | 1.5484 | 3.02E-32 | 1.6888 | 3.30E-15 | 1.3892 | 2.10E-07 | 2.0161 | 1.33E-67 | |||
| TBX3 | 1.4951 | 4.79E-31 | 1.3848 | 1.96E-13 | 1.9755 | 3.53E-05 | 2.1108 | 1.26E-71 | |||
| JAM2 | 1.4844 | 7.69E-50 | 1.9511 | 8.55E-20 | 1.8270 | 7.72E-08 | 2.4928 | 1.57E-150 | |||
| CD93 | 1.4564 | 1.46E-28 | 1.6924 | 7.67E-17 | 1.8429 | 6.54E-07 | 2.1842 | 5.72E-103 | |||
| GHR | 1.4503 | 5.31E-33 | 1.8830 | 2.24E-15 | 1.5769 | 5.72E-04 | 2.0160 | 2.21E-45 | |||
| STXBP6 | 1.4350 | 1.56E-46 | 2.6371 | 1.02E-19 | 2.9172 | 2.99E-11 | 3.3623 | 3.84E-103 | |||
| TMEM47 | 1.4317 | 2.40E-18 | 1.4365 | 1.25E-12 | 1.3715 | 1.49E-04 | 1.7287 | 2.81E-55 | |||
| FERMT2 | 1.3605 | 4.41E-31 | 1.2932 | 7.35E-08 | 1.0452 | 5.26E-05 | 1.3922 | 9.59E-63 | |||
| SEMA6A | 1.3278 | 9.00E-21 | 1.6010 | 4.60E-12 | 2.3603 | 1.33E-10 | 2.5439 | 1.49E-95 | |||
| SEMA5A | 1.3200 | 1.03E-30 | 1.5949 | 8.43E-19 | 1.9359 | 2.09E-05 | 2.5148 | 6.65E-77 | |||
| PTPRB | 1.3143 | 3.05E-36 | 2.1648 | 7.02E-21 | 1.9385 | 1.05E-05 | 2.5855 | 1.33E-119 | |||
| CALCRL | 1.3001 | 2.6E-22 | 2.0359 | 2.50E-09 | 2.2940 | 1.28E-04 | 2.7443 | 8.75E-150 | |||
| SASH1 | 1.2749 | 2.18E-41 | 1.4206 | 4.38E-18 | 1.6155 | 2.34E-08 | 1.8352 | 2.13E-102 | |||
| S1PR1 | 1.2691 | 1.09E-40 | 2.0206 | 1.38E-22 | 2.0551 | 8.06E-06 | 2.8252 | 4.29E-189 | |||
| LMCD1 | 1.2579 | 5.45E-29 | 1.1033 | 1.87E-13 | 1.4161 | 3.59E-04 | 1.7207 | 8.72E-84 | |||
| SPTBN1 | 1.2511 | 6.33E-24 | 1.6536 | 2.06E-09 | 1.5544 | 6.94E-06 | 1.7150 | 1.41E-95 | |||
| EML1 | 1.2483 | 1.09E-35 | 1.4229 | 2.21E-12 | 1.3991 | 4.63E-06 | 1.6725 | 2.98E-51 | |||
| PODXL | 1.1869 | 1.80E-26 | 1.1076 | 3.11E-15 | 1.2530 | 7.96E-05 | 1.0640 | 3.71E-28 | |||
| KL | 1.1122 | 5.76E-30 | 2.2987 | 2.82E-24 | 2.0117 | 3.83E-05 | 2.3051 | 2.19E-41 | |||
| PDK4 | 1.1117 | 3.07E-18 | 1.8544 | 1.058E-06 | 1.8622 | 4.63E-04 | 2.3871 | 2.32E-53 | |||
DEG, differentially expressed gene; FC, fold change; FDR, false discovery rate.