. 2021 Jun;10(6):3111–3127. doi: 10.21037/tcr-20-2813

Table 1. miRNA expression and its possible role in GC.

miRNAs related to vitamin D	Potential role in GC	Expression in GC	Therapeutic potential in GC	Reference
miR-125	Oncogene	Upregulated	Possible role in CDDP sensitivity and Trastuzumab resistance in GC cells	(80-83)
miR-125	TS	Downregulated		(80-83)
miR-145	TS	Downregulated	Possible role improving chemosensitivity to CDDP and 5FU in GC cells	(84,85)
miR-99	Oncogene	Upregulated	Associated with CDDP resistance in GC cells	(86,87)
miR-99	TS	Downregulated	Associated with CDDP resistance in GC cells	(86,87)
miR-498	TS	Downregulated	Possible role in overcoming CDDP resistance in GC cells	(88,89)
miR-22	TS	Downregulated	Possible role in CDDP resistance in GC cells	(90-92)
miR-181	Oncogene	Upregulated	–	(93-95)
miR-181	TS	Downregulated	–	(93-95)
miR-106	Oncogene	Upregulated	–	(96,97)
miR-532	Oncogene	Upregulated	–	(98,99)
miR-532	TS	Downregulated	–	(98,99)

GC, gastric cancer; miR, microRNA; TS, tumor suppressor; CDDP, cisplatin; 5FU, 5-fluorouracil.