Table 4. Univariate and multivariate Cox’s proportional hazard regression model analyses of factors predicting OS.
| Items | Cox’s proportional hazard regression model | |||
|---|---|---|---|---|
| P value | HR | 95%CI | ||
| Lower | Higher | |||
| Univariate Cox’s regression | ||||
| Circ-ITCH high expression | 0.022 | 0.367 | 0.156 | 0.865 |
| Age (≥60 years) | 0.688 | 0.846 | 0.373 | 1.918 |
| Gender (male) | 0.145 | 0.557 | 0.254 | 1.223 |
| Immunophenotype (IgG vs. others) | 0.571 | 1.260 | 0.566 | 2.808 |
| Bone lesion | 0.022 | 5.409 | 1.272 | 23.002 |
| Hb (≥10.0 g/dL) | 0.390 | 1.421 | 0.638 | 3.165 |
| Calcium (≥11.5 mg/dL) | 0.478 | 1.356 | 0.585 | 3.146 |
| Scr (≥2.0 mg/dL) | 0.771 | 1.158 | 0.431 | 3.109 |
| Albumin (≥3.5 mg/dL) | 0.615 | 1.266 | 0.504 | 3.182 |
| β2-MG (≥5.5 mg/L) | <0.001 | 20.320 | 6.919 | 59.677 |
| LDH (≥220.0 U/L) | 0.381 | 1.443 | 0.635 | 3.279 |
| Durie-Salmon stage (III vs. II) | 0.115 | 4.998 | 0.674 | 37.070 |
| Higher ISS stage | <0.001 | 10.598 | 4.264 | 26.343 |
| t(4;14) | 0.060 | 2.569 | 0.962 | 6.860 |
| t(14;16) | 0.011 | 2.997 | 1.292 | 6.954 |
| Del (17p) | 0.002 | 4.429 | 1.744 | 11.249 |
| Forward stepwise multivariate Cox’s regression | ||||
| β2-MG (≥5.5 mg/L) | <0.001 | 37.864 | 10.126 | 141.577 |
| t(4;14) | 0.019 | 3.430 | 1.225 | 9.604 |
| t(14;16) | 0.006 | 3.433 | 1.432 | 8.234 |
OS, overall survival; HR, hazard ratio; CI, confidence interval; Ig, immunoglobulin; Hb, hemoglobin; Scr, serum creatinine; β2-MG, β2-microglobulin; LDH, lactate dehydrogenase; ISS, international staging system.