Table 1. Clinical and pathologic characteristics of the CRC cases with MET and miR-133b mRNA expression.
| Clinicopathological features | Number | miR-133b | MET | |||||
|---|---|---|---|---|---|---|---|---|
| Lowa (n=23) | Higha (n=23) | P value | Lowa (n=23) | Higha (n=23) | P value | |||
| Age (years) | 46 | |||||||
| ≥60 | 34 | 15 | 19 | 0.397 | 20 | 14 | 0.318 | |
| <60 | 12 | 7 | 5 | 9 | 3 | |||
| Tumor siteb | ||||||||
| Right | 13 | 7 | 6 | 0.528 | 4 | 9 | 0.178 | |
| Left | 7 | 2 | 5 | 3 | 4 | |||
| Rectum | 26 | 13 | 13 | 16 | 10 | |||
| Tumor differentiation | ||||||||
| Well | 2 | 0 | 2 | 0.138 | 1 | 1 | 0.712 | |
| Moderate | 28 | 11 | 17 | 12 | 16 | |||
| Poor | 16 | 10 | 6 | 5 | 11 | |||
| Staging | ||||||||
| I | 6 | 3 | 3 | 0.432 | 4 | 2 | 0.677 | |
| II | 11 | 6 | 5 | 7 | 4 | |||
| III | 25 | 19 | 6 | 12 | 13 | |||
| IV | 4 | 4 | 0 | 0 | 4 | |||
| Lymph node | ||||||||
| N0 | 18 | 5 | 13 | 0.028b | 10 | 8 | 0.032b | |
| N1 | 21 | 8 | 13 | 17 | 4 | |||
| N2 | 7 | 6 | 1 | 2 | 5 | |||
| Distant metastasis | ||||||||
| M0 | 42 | 17 | 25 | 0.022b | 31 | 11 | 0.003b | |
| M1 | 4 | 4 | 0 | 0 | 4 | |||
a, low and high expression groups were determined by the median value of MET and miR-133b mRNA in the tumor tissue specimens; b, statistical significance (P<0.05). CRC, colorectal cancer; MET, mesenchymal-epithelial transition factor.