Table 1. Clinical and pathologic characteristics of the CRC cases with MET and miR-133b mRNA expression.
Clinicopathological features | Number | miR-133b | MET | |||||
---|---|---|---|---|---|---|---|---|
Lowa (n=23) | Higha (n=23) | P value | Lowa (n=23) | Higha (n=23) | P value | |||
Age (years) | 46 | |||||||
≥60 | 34 | 15 | 19 | 0.397 | 20 | 14 | 0.318 | |
<60 | 12 | 7 | 5 | 9 | 3 | |||
Tumor siteb | ||||||||
Right | 13 | 7 | 6 | 0.528 | 4 | 9 | 0.178 | |
Left | 7 | 2 | 5 | 3 | 4 | |||
Rectum | 26 | 13 | 13 | 16 | 10 | |||
Tumor differentiation | ||||||||
Well | 2 | 0 | 2 | 0.138 | 1 | 1 | 0.712 | |
Moderate | 28 | 11 | 17 | 12 | 16 | |||
Poor | 16 | 10 | 6 | 5 | 11 | |||
Staging | ||||||||
I | 6 | 3 | 3 | 0.432 | 4 | 2 | 0.677 | |
II | 11 | 6 | 5 | 7 | 4 | |||
III | 25 | 19 | 6 | 12 | 13 | |||
IV | 4 | 4 | 0 | 0 | 4 | |||
Lymph node | ||||||||
N0 | 18 | 5 | 13 | 0.028b | 10 | 8 | 0.032b | |
N1 | 21 | 8 | 13 | 17 | 4 | |||
N2 | 7 | 6 | 1 | 2 | 5 | |||
Distant metastasis | ||||||||
M0 | 42 | 17 | 25 | 0.022b | 31 | 11 | 0.003b | |
M1 | 4 | 4 | 0 | 0 | 4 |
a, low and high expression groups were determined by the median value of MET and miR-133b mRNA in the tumor tissue specimens; b, statistical significance (P<0.05). CRC, colorectal cancer; MET, mesenchymal-epithelial transition factor.