Table 1. Correlation between clinicopathologic variables and IL-10 methylation index in HCC.

Variable	Cases (120)	∆MI ≤0 (N=80)	∆MI >0 (N=40)	P*
Gender				0.146
Male	96	67	29
Female	24	13	11
Age (y)				0.320
≥50	85	59	26
<50	35	21	14
HBV history				0.760
Yes	92	62	30
No	28	18	10
Differentiation				0.429
G1	48	30	18
G2-3	72	50	22
Cirrhosis				0.781
Yes	82	54	28
No	38	26	12
Tobacco				0.135
Yes	76	49	37
No	44	31	13
Alcohol				0.358
Yes	71	45	26
No	49	35	14
Lymph node status				0.417
N0	42	26	16
N1	78	54	24
Metastasis classification				0.001
M0	53	27	26
M1	67	53	14
AFP (µg/L)				0.005
≥30	82	63	19
<30	38	17	21

*, statistical significance determined by Pearson’s Chi-squared test. IL-10, interleukin-10; HCC, hepatocellular carcinoma; MI, methylation index; HBV, hepatitis B virus; AFP, α-fetoprotein.