| Stage IIIB to IV NSCLC |
Carboplatin + nab-paclitaxel/solvent-based paclitaxel |
959 |
Quartiles based on DpR (NTR: had no shrinkage, Q1:>0% to 25%, Q2: >25% to 50%, Q3: >50% to 75%, Q4: >75%); NTR vs. Q1 vs. Q2 vs. Q3 vs. Q4 vs. Q5, mPFS (2.7 vs. 5.6 vs. 6.9 vs. 8.3 vs. 10.9 months, HR: 0.22, 0.17, 0.13, 0.08, P<0.0001); mOS (4.8 vs. 10.4 vs. 14.5 vs. 19.3 vs. 23.5 months, HR: 0.39, 0.27, 0.20, 0.15, P<0.0001) |
(37) |
| No-Squamous NSCLC |
Paclitaxel + carboplatin + bevacizum Ab |
80 |
DpR<30% vs. 30%≤ DpR <60% vs. DpR ≥60%; PFS (10.6 vs. 8.2 vs. 6.4 months, P<0.001) |
(37) |
| Extensive SCLC |
Chemotherapy |
50 |
Quartiles based on DpR (Q1=0–25%, Q2=26–50%, Q3=51–75%, Q4=76–100%); Q1 vs. Q2 vs. Q3 vs. Q4, mPFS (4.3 vs. 9.3 vs. 8.6 vs. 8.9 months, P<0.0001); mOS (7.2 vs. 13.6 vs. 12.6 vs. 13.7 months, P<0.0001); correlation between DpR and outcomes (PFS: rs=0.67; OS: rs=0.64) |
(38) |
| Locally advanced NSCLC or IV NSCLC (ALK+) |
ALK inhibitor |
305 |
Quartiles based on DpR (NTR: had no shrinkage, Q1=1–25%, Q2= 26–50%, Q3=51–75%,Q4=76–100%); correlation between DpR and outcomes, HR (95% CI) for PFS (Q1 to Q4 compared to NTR): 0.19 (0.09, 0.40), 0.11 (0.06, 0.24), 0.05 (0.03, 0.11), 0.03 (0.02, 0.07); for OS (Q1 to Q4): 0.94 (0.34, 2.61), 0.56 (0.21, 1.51); 0.28 (0.11, 0.73), 0.05 (0.01, 0.28) |
(39) |
| Advanced NSCLC |
EGFR-TKI |
265 |
Quartiles based on DpR (Q1=1–25%, Q2=26–50%, Q3=51–75%, Q4=76–100%); HR (95% CI) for PFS (Q2 to Q4 compared to Q1): 0.58 (0.42, 0.80), 0.49 (0.35, 0.69), 0.33 (0.22, 0.50) |
(40) |
| Advanced NSCLC |
EGFR-TKI |
98 |
DpR not associated with outcomes, high vs. low shrinkage in CR+PR for PFS: Week 8: HR 1.30 (95% CI, 0.71, 2.38), P=0.391; Week 16.5: HR 0.99 (95% CI, 0.60, 1.63), P=0.956; Week 56: HR 1.02 (95% CI, 0.48, 2.18), P=0.958; high vs. low shrinkage in CR+PR for OS: Week 8: HR 1.31 (95% CI, 0.68–2.55), P=0.421; Week 16.5: HR 1.36 (95% CI, 0.77–2.41), P=0.289; Week 56: HR 1.02 (95% CI, 0.55–1.91), P=0.940 |
(41) |
| Advanced NSCLC |
EGFR-TKI |
1,081 |
DpR at week 6 not associated with outcomes, PFS: HR 0.96 (95% CI, 0.70–1.30), P=0.78; OS: HR 0.83 (95% CI, 0.60–1.15), P=0.26 |
(42) |
| IIIB or IV NSCLC |
PD-1 inhibitor |
355 |
Quartiles based on DpR (NTR: had no shrinkage; Q1=1–25%, Q2=26–50%, Q3=51–75%, Q4=76–100%); correlation between DpR and outcomes, HR (95% CI) for PFS (Q1 to Q4 compared to NTR): 0.30 (95% CI, 0.22–0.41), 0.22 (95% CI, 0.15–0.32), 0.09 (95% CI, 0.06–0.15, 0.07 (95% CI, 0.03–0.12); HR for OS (Q1 to Q4): 0.52 (95% CI, 0.37–0.74), 0.47 (95% CI, 0.30–0.74), 0.07 (95% CI, 0.03–0.18), 0.14 (95% CI, 0.06–0.32) |
(39) |
| Advanced NSCLC |
Nivolumab |
31 |
DpR ≥10% vs. <10% at weeks 8 to 12: PFS:16.6 vs. 5.1 months, P<0.001 |
(43) |
