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. 2020 Apr;9(4):2576–2587. doi: 10.21037/tcr.2020.02.68

Figure 2.

Figure 2

Downregulated expression level of miR-29b in the CAF-derived exosomes isolated from HCC patients. (A) Heatmap showing the profiles of differentially expressed miRNA between CAF- and PAF-derived exosomes. Green: miRNAs expressed at low levels; red: miRNAs expressed at high levels; and black: miRNAs with similar expression patterns. (B) Profiles of differentially expressed miRNAs between CAF- and PAF-derived exosomes. Blue: miRNAs expressed at high levels; purplish red: miRNAs expressed at low levels; and pink: miRNAs with similar expression patterns. (C) Relative normalized expression levels of miR-29b in CAF- and PAF-derived exosomes (n=3 per group), as revealed by miRNA sequencing. (D) qRT-PCR analysis of miR-29b expression in HepG2 and Huh7 cells, CAFs, PAFs and PAFs stimulated with 10 ng/mL TGF-β. *, P<0.05 compared with each group. CAF, cancer-associated stromal fibroblast; HCC, hepatocellular carcinoma; PAF, paracancerous fibroblast.