Table 3. Univariate and multivariate Cox proportional hazards analyses for disease-free survival and overall survival.

Variable	Progression-free survival			Overall survival
	HR (95% CI)	P value		HR (95% CI)	P value
Univariate
Age (y)
<60	1			1
≥60	0.868 (0.499–1.508)	0.615		0.893 (0.463–1.724)	0.737
Gender
Male	1			1
Female	1.917 (1.013–3.629)	0.046*		1.091 (0.497–2.395)	0.829
Histopathology
Adenocarcinoma	1			1
Squama	1.782 (0.241–13.193)	0.571		0.791 (0.104–5.994)	0.821
Othersa	0.597 (0.078–4.564)	0.619		0.547 (0.072–4.177)	0.561
Lymph node metastasis
No	1			1
Yes	1.028 (0.574–1.841)	0.926		1.407 (0.678–2.922)	0.359
TNM stage
I–II	1			1
III–IV	2.662 (1.523–4.652)	0.001*		2.846 (1.476–5.488)	0.002*
Differentiation group
Poor	1			1
Good-moderate	0.625 (0.386–1.010)	0.055		0.732 (0.412–1.302)	0.289
Smoking history
No	1			1
Yes	0.496 (0.272–0.905)	0.496		0.942 (0.443–2.005)	0.877
JMJD5
Low	1			1
High	2.340 (1.286–4.257)	0.005*		2.950 (1.507–5.776)	0.002*
Multivariate
Gender
Male	1			1
Female	1.624 (0.850–3.105)	0.142		0.921 (0.416–2.039)	0.839
TNM stage
I–II	1			1
III–IV	2.210 (1.244–3.926)	0.007		2.324 (1.163–4.646)	0.017*
Differentiation group
Poor	1			1
Good-moderate	0.728 (0.437–1.212)	0.222		0.938 (0.506–1.737)	0.838
JMJD5
Low	1			1
High	2.031 (1.095–3.767)	0.025		2.339 (1.158–4.724)	0.018*

^a, others including adenosquamous carcinoma, large cell carcinoma, sarcoma, etc. Data were analyzed by chi-square test. Univariate and multivariate analysis was done using the Cox proportional hazard regression analysis. *, P<0.05. CI, confidence interval.