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. 2021 Dec 15;10:e60360. doi: 10.7554/eLife.60360

Figure 5. Transient inhibition of Ca2+-calmodulin-dependent kinase II (CaMKII) enhances subsequent long-term potentiation (LTP).

Figure 5.

(A) Timeline of experimental procedure. Following in utero electroporation acute slices were prepared at P15–P25. Slices were then exposed to blue light for 40 min. Paired recordings were then made from a control cell (black circles) and a paAIP2 expressing cell (green circles). (B) One representative experiment showing that prior paAIP2 activation reduced baseline AMPAR EPSCs, but LTP was larger than that recorded in the neighboring control cell. (C) Normalized representative experiment showing that prior paAIP2 activation increased LTP. (D) Summary data showing that prior paAIP2 activation reduced baseline AMPAR EPSCs, but enhanced LTP (n = 5). (E) Normalized summary data showing that prior paAIP2 activation doubles the size of LTP. n = 5, p < 0.01, two-tailed Wilcoxon Signed Rank Test. Mean ± standard error of the mean (SEM).

Figure 5—source data 1. Transient inhibition of Ca2+-calmodulin-dependent kinase II (CaMKII) enhances subsequent long-term potentiation (LTP).
In this dataset, the results of the effects of LTP induction on control cells and preinhibition cells are included.