Table S3. mxzl vs. control.
| sRNA | yyp | lfz | Log2 fold change | P value | Q value (Storey et al. 2003) |
|---|---|---|---|---|---|
| Up-regulated | |||||
| hsa-miR-143-3p | 11,510.45 | 241.2097 | 5.5765 | 0 | 0 |
| hsa-miR-146b-5p | 2,419.833 | 410.3383 | 2.56 | 0 | 0 |
| hsa-miR-148a-3p | 70,326.8 | 17,813.54 | 1.9811 | 0 | 0 |
| hsa-miR-199b-5p | 4,105.741 | 19.46322 | 7.7207 | 0 | 0 |
| hsa-miR-20a-5p | 4,805.136 | 1,288.331 | 1.8991 | 0 | 0 |
| hsa-miR-21-5p | 28,309.18 | 4,955.872 | 2.5141 | 0 | 0 |
| hsa-miR-221-3p | 1,682.975 | 202.9544 | 3.0518 | 0 | 0 |
| hsa-miR-222-3p | 1,349.408 | 157.4507 | 3.0994 | 0 | 0 |
| hsa-miR-223-3p | 12,870.55 | 343.7607 | 5.2265 | 0 | 0 |
| hsa-miR-23a-3p | 3,295.188 | 544.0304 | 2.5986 | 0 | 0 |
| hsa-miR-24-3p | 2,006.894 | 377.5864 | 2.4101 | 0 | 0 |
| hsa-miR-26a-5p | 30,229.04 | 10,386.38 | 1.5412 | 0 | 0 |
| hsa-miR-27a-3p | 1,451.578 | 245.2365 | 2.5654 | 0 | 0 |
| hsa-miR-27b-3p | 2,315.865 | 444.9694 | 2.3798 | 0 | 0 |
| hsa-miR-3074-5p | 1,987.784 | 376.6468 | 2.3999 | 0 | 0 |
| hsa-miR-30b-5p | 1,378.356 | 171.0078 | 3.0108 | 0 | 0 |
| hsa-miR-30c-5p | 3,641.622 | 1,384.439 | 1.3953 | 0 | 0 |
| hsa-miR-582-3p | 1,384.41 | 6.711454 | 7.6884 | 0 | 0 |
| hsa-miR-181a-5p | 3,281.849 | 1,623.366 | 1.0155 | 1.48E-303 | 3.76E-302 |
| hsa-miR-142-3p | 1,687.895 | 415.5732 | 2.0221 | 6.37E-297 | 1.57E-295 |
| hsa-miR-340-5p | 1,226.519 | 188.5919 | 2.7012 | 1.57E-272 | 3.75E-271 |
| hsa-miR-145-5p | 815.2829 | 14.7652 | 5.787 | 2.17E-236 | 4.87E-235 |
| hsa-miR-199a-3p | 769.2115 | 37.31568 | 4.3655 | 8.56E-220 | 1.82E-218 |
| hsa-miR-146a-5p | 925.4946 | 168.0548 | 2.4613 | 2.56E-192 | 5.17E-191 |
| hsa-miR-155-5p | 773.0902 | 86.84621 | 3.1541 | 3.57E-191 | 7.03E-190 |
| hsa-miR-29a-3p | 752.4669 | 121.0746 | 2.6357 | 5.12E-165 | 9.83E-164 |
| hsa-miR-361-3p | 1,385.262 | 605.5074 | 1.1939 | 2.54E-150 | 4.75E-149 |
| hsa-miR-28-3p | 612.7393 | 79.06093 | 2.9542 | 8.02E-146 | 1.43E-144 |
| hsa-miR-221-5p | 503.0006 | 29.79886 | 4.0772 | 1.77E-141 | 2.90E-140 |
| hsa-miR-374b-5p | 1,284.321 | 598.7959 | 1.1009 | 2.90E-129 | 4.48E-128 |
| hsa-miR-374c-3p | 1,283.281 | 598.3932 | 1.1007 | 3.87E-129 | 5.85E-128 |
| hsa-miR-197-3p | 506.0279 | 64.42996 | 2.9734 | 2.81E-121 | 3.95E-120 |
| hsa-miR-106b-5p | 830.0408 | 296.512 | 1.4851 | 2.32E-111 | 3.20E-110 |
| hsa-miR-450a-5p | 392.8835 | 44.42982 | 3.1445 | 6.05E-98 | 7.80E-97 |
| hsa-miR-582-5p | 341.3252 | 1.610749 | 7.7273 | 1.88E-87 | 2.24E-86 |
| hsa-miR-223-5p | 404.8034 | 76.91326 | 2.3959 | 1.84E-83 | 2.16E-82 |
| hsa-miR-181a-3p | 254.5749 | 6.442996 | 5.3042 | 8.11E-76 | 9.39E-75 |
| hsa-miR-181b-5p | 262.1431 | 28.72502 | 3.19 | 1.55E-66 | 1.72E-65 |
| hsa-miR-424-5p | 206.9899 | 8.053745 | 4.6838 | 1.89E-61 | 2.06E-60 |
| hsa-miR-769-5p | 203.5842 | 21.47665 | 3.2448 | 1.37E-52 | 1.46E-51 |
| hsa-miR-342-3p | 218.2476 | 30.06731 | 2.8597 | 4.92E-52 | 5.10E-51 |
| hsa-miR-450b-5p | 163.7566 | 6.308767 | 4.6981 | 5.14E-49 | 5.25E-48 |
| hsa-miR-618 | 171.514 | 16.91286 | 3.3421 | 2.58E-45 | 2.60E-44 |
| hsa-miR-100-5p | 148.9041 | 4.563789 | 5.028 | 4.66E-45 | 4.64E-44 |
| hsa-miR-140-5p | 211.8146 | 40.40295 | 2.3903 | 1.87E-44 | 1.84E-43 |
| hsa-miR-27a-5p | 131.4972 | 7.651057 | 4.1032 | 2.03E-38 | 1.94E-37 |
| hsa-miR-424-3p | 187.0288 | 40.67141 | 2.2012 | 5.36E-37 | 5.08E-36 |
| hsa-miR-148a-5p | 121.6586 | 12.75176 | 3.2541 | 3.56E-32 | 3.34E-31 |
| hsa-miR-19b-3p | 255.8993 | 104.296 | 1.2949 | 1.96E-31 | 1.82E-30 |
| hsa-miR-150-5p | 292.6996 | 138.6586 | 1.0779 | 3.01E-30 | 2.76E-29 |
| hsa-miR-425-3p | 221.5587 | 84.69855 | 1.3873 | 3.45E-29 | 3.12E-28 |
| hsa-miR-651-5p | 116.6447 | 19.32899 | 2.5933 | 8.89E-27 | 7.77E-26 |
| hsa-miR-542-3p | 87.88556 | 4.832247 | 4.1849 | 2.15E-26 | 1.84E-25 |
| hsa-miR-99b-5p | 81.0742 | 3.758414 | 4.431 | 7.61E-25 | 6.37E-24 |
| hsa-miR-24-2-5p | 92.89949 | 11.27524 | 3.0425 | 5.09E-24 | 4.17E-23 |
| hsa-miR-10a-5p | 112.6714 | 23.0874 | 2.2869 | 1.24E-23 | 1.01E-22 |
| hsa-miR-181d-5p | 69.53271 | 1.073833 | 6.0169 | 1.33E-21 | 1.04E-20 |
| hsa-miR-145-3p | 68.39748 | 2.281894 | 4.9056 | 1.47E-21 | 1.13E-20 |
| hsa-miR-4521 | 61.86992 | 3.355727 | 4.2045 | 4.42E-19 | 3.25E-18 |
| hsa-miR-361-5p | 92.52108 | 20.67128 | 2.1622 | 7.27E-19 | 5.30E-18 |
| hsa-miR-345-5p | 120.0504 | 42.9533 | 1.4828 | 1.60E-17 | 1.15E-16 |
| hsa-miR-3065-3p | 57.61282 | 4.161101 | 3.7914 | 2.95E-17 | 2.11E-16 |
| hsa-miR-338-5p | 57.32901 | 4.161101 | 3.7842 | 3.62E-17 | 2.57E-16 |
| hsa-miR-660-5p | 156.8507 | 75.16828 | 1.0612 | 1.01E-16 | 7.08E-16 |
| hsa-miR-126-5p | 121.3748 | 51.54397 | 1.2356 | 4.02E-15 | 2.73E-14 |
| hsa-miR-181c-3p | 48.7202 | 0 | 6.9187 | 7.60E-15 | 5.07E-14 |
| hsa-miR-362-5p | 80.22278 | 22.1478 | 1.8568 | 1.09E-14 | 7.20E-14 |
| hsa-miR-199a-5p | 59.03185 | 10.73833 | 2.4587 | 8.23E-14 | 5.40E-13 |
| hsa-miR-125a-5p | 49.38242 | 5.503392 | 3.1656 | 8.57E-14 | 5.57E-13 |
| hsa-miR-152-3p | 56.856 | 10.06718 | 2.4977 | 1.67E-13 | 1.07E-12 |
| hsa-miR-34c-5p | 40.30059 | 1.073833 | 5.23 | 2.27E-13 | 1.44E-12 |
| hsa-miR-16-2-3p | 94.98074 | 40.40295 | 1.2332 | 3.88E-12 | 2.42E-11 |
| hsa-miR-9-5p | 45.78753 | 7.24837 | 2.6592 | 1.25E-11 | 7.73E-11 |
| hsa-miR-505-3p | 60.7347 | 17.04709 | 1.833 | 2.30E-11 | 1.42E-10 |
| hsa-miR-28-5p | 40.30059 | 4.966476 | 3.0205 | 3.09E-11 | 1.89E-10 |
| hsa-miR-652-5p | 30.36735 | 0 | 5.2367 | 1.96E-10 | 1.18E-09 |
| hsa-miR-4286 | 29.61053 | 0 | 4.9779 | 3.41E-10 | 2.03E-09 |
| hsa-miR-143-5p | 26.67786 | 0 | 5.7376 | 2.80E-09 | 1.65E-08 |
| hsa-miR-146b-3p | 55.53157 | 19.46322 | 1.5126 | 4.95E-09 | 2.88E-08 |
| hsa-miR-34a-5p | 25.73183 | 1.342291 | 4.2608 | 8.02E-09 | 4.64E-08 |
| hsa-miR-21-3p | 29.89434 | 5.234934 | 2.5136 | 8.36E-08 | 4.71E-07 |
| hsa-miR-330-3p | 27.52928 | 4.026872 | 2.7732 | 9.65E-08 | 5.39E-07 |
| hsa-miR-574-3p | 53.16651 | 23.0874 | 1.2034 | 2.85E-07 | 1.57E-06 |
| hsa-miR-874-3p | 19.77189 | 0 | 4.6176 | 3.30E-07 | 1.80E-06 |
| hsa-miR-29c-3p | 31.69178 | 8.456432 | 1.906 | 8.89E-07 | 4.76E-06 |
| hsa-let-7e-5p | 32.25939 | 9.261806 | 1.8004 | 1.35E-06 | 7.16E-06 |
| hsa-miR-335-3p | 17.40683 | 0 | 4.6969 | 1.61E-06 | 8.43E-06 |
| hsa-miR-374b-3p | 22.32615 | 4.42956 | 2.3335 | 6.88E-06 | 3.45E-05 |
| hsa-miR-365a-3p | 22.89376 | 5.637621 | 2.0218 | 1.81E-05 | 8.96E-05 |
| hsa-miR-548e-3p | 34.05684 | 13.95982 | 1.2867 | 2.22E-05 | 0.00010847 |
| hsa-miR-181c-5p | 13.52813 | 0 | 5.6551 | 2.27E-05 | 0.00011028 |
| hsa-miR-30c-1-3p | 17.59603 | 2.95304 | 2.575 | 3.33E-05 | 0.00015988 |
| hsa-miR-30d-3p | 19.86649 | 4.29533 | 2.2095 | 3.35E-05 | 0.00015996 |
| hsa-miR-200b-3p | 14.47416 | 1.342291 | 3.4307 | 3.58E-05 | 0.0001695 |
| hsa-miR-4454 | 12.96052 | 0 | 4.2714 | 4.22E-05 | 0.00019655 |
| hsa-miR-32-3p | 20.2449 | 4.832247 | 2.0668 | 4.70E-05 | 0.00021618 |
| hsa-miR-2115-3p | 12.67671 | 0 | 3.9764 | 6.29E-05 | 0.00028622 |
| hsa-miR-671-3p | 14.28495 | 1.879207 | 2.9263 | 9.10E-05 | 0.00040916 |
| hsa-miR-7-1-3p | 18.25825 | 4.29533 | 2.0877 | 0.000104 | 0.00046299 |
| hsa-miR-766-3p | 15.70399 | 2.818811 | 2.478 | 0.000112 | 0.00049842 |
| hsa-miR-2355-3p | 11.35228 | 0 | 4.4021 | 0.000119 | 0.00052583 |
| hsa-miR-1273h-3p | 13.05512 | 1.610749 | 3.0188 | 0.000157 | 0.00068653 |
| hsa-miR-193a-5p | 22.89376 | 8.053745 | 1.5072 | 0.000177 | 0.00076703 |
| hsa-miR-491-5p | 11.54148 | 1.208062 | 3.2561 | 0.000275 | 0.0011652 |
| hsa-miR-671-5p | 10.02785 | 0 | 6.2232 | 0.000308 | 0.0012841 |
| hsa-miR-3065-5p | 9.649438 | 0 | 4.5827 | 0.000365 | 0.0014968 |
| hsa-miR-338-3p | 9.649438 | 0 | 4.5827 | 0.000365 | 0.0014968 |
| hsa-miR-26b-3p | 21.28552 | 7.785286 | 1.4511 | 0.000384 | 0.001566 |
| hsa-miR-25-5p | 15.32558 | 4.563789 | 1.7476 | 0.001015 | 0.0039956 |
| hsa-miR-1255a | 8.230403 | 0 | 4.3532 | 0.001068 | 0.0041816 |
| hsa-miR-16-1-3p | 8.419607 | 0 | 3.6491 | 0.001365 | 0.0052082 |
| hsa-miR-200c-3p | 20.52871 | 8.859119 | 1.2124 | 0.00137 | 0.0052082 |
| hsa-miR-139-5p | 11.91989 | 3.221498 | 1.8876 | 0.002691 | 0.010036 |
| hsa-miR-6503-3p | 7.189777 | 0 | 3.7432 | 0.002918 | 0.010833 |
| hsa-miR-4772-5p | 6.811368 | 0 | 4.0802 | 0.003209 | 0.0118 |
| hsa-miR-4677-3p | 12.1091 | 3.892643 | 1.6373 | 0.00459 | 0.016802 |
| hsa-miR-2115-5p | 6.338356 | 0 | 3.9764 | 0.004661 | 0.016984 |
| hsa-miR-628-5p | 6.527561 | 0 | 3.6038 | 0.004941 | 0.01792 |
| hsa-miR-381-3p | 10.21705 | 2.684582 | 1.9282 | 0.005033 | 0.018087 |
| hsa-miR-296-3p | 6.338356 | 0 | 3.6641 | 0.005422 | 0.019397 |
| hsa-miR-1307-5p | 8.51421 | 2.013436 | 2.0802 | 0.008123 | 0.028538 |
| hsa-miR-33a-3p | 6.149151 | 0 | 3.1957 | 0.008281 | 0.028964 |
| hsa-miR-1250-5p | 5.959947 | 0 | 3.1506 | 0.009645 | 0.033291 |
| hsa-miR-4645-3p | 5.013923 | 0 | 3.6382 | 0.013544 | 0.045747 |
| hsa-miR-499a-5p | 12.86592 | 5.906079 | 1.1233 | 0.014552 | 0.048734 |
| Down-regulated | |||||
| hsa-let-7a-5p | 13,005.93 | 35,647.22 | −1.4546 | 0 | 0 |
| hsa-let-7b-5p | 3,975.757 | 12,791.09 | −1.6858 | 0 | 0 |
| hsa-let-7i-5p | 44,505.29 | 120,866 | −1.4414 | 0 | 0 |
| hsa-miR-25-3p | 12,852.29 | 44,411.7 | −1.7889 | 0 | 0 |
| hsa-miR-486-3p | 9,452.381 | 86,019.36 | −3.1859 | 0 | 0 |
| hsa-miR-486-5p | 9,647.451 | 87,202.59 | −3.1762 | 0 | 0 |
| hsa-miR-92a-3p | 12,505.86 | 53,627.6 | −2.1004 | 0 | 0 |
| hsa-miR-151a-3p | 788.5104 | 3,640.695 | −2.207 | 7.14E-250 | 1.65E-248 |
| hsa-miR-183-5p | 1,006.285 | 3,816.67 | −1.9233 | 5.32E-199 | 1.10E-197 |
| hsa-miR-106b-3p | 2,674.313 | 6,842.461 | −1.3553 | 3.02E-150 | 5.53E-149 |
| hsa-miR-3184-3p | 2,537.802 | 6,521.385 | −1.3616 | 3.75E-145 | 6.42E-144 |
| hsa-miR-423-5p | 2,537.802 | 6,521.385 | −1.3616 | 3.75E-145 | 6.42E-144 |
| hsa-miR-3158-5p | 217.8692 | 1,386.586 | −2.67 | 1.69E-133 | 2.72E-132 |
| hsa-miR-3158-3p | 218.7206 | 1,386.855 | −2.6647 | 4.19E-133 | 6.60E-132 |
| hsa-let-7c-5p | 535.8276 | 2,053.973 | −1.9386 | 9.96E-110 | 1.33E-108 |
| hsa-miR-30a-5p | 29.32672 | 592.7556 | −4.3371 | 1.30E-102 | 1.70E-101 |
| hsa-let-7d-5p | 837.9874 | 2,560.688 | −1.6115 | 6.17E-90 | 7.71E-89 |
| hsa-miR-3615 | 177.947 | 1,014.101 | −2.5107 | 6.64E-89 | 8.17E-88 |
| hsa-miR-144-3p | 311.7147 | 1,365.647 | −2.1313 | 7.73E-89 | 9.37E-88 |
| hsa-miR-584-5p | 67.64067 | 604.0308 | −3.1587 | 3.64E-75 | 4.15E-74 |
| hsa-miR-363-3p | 2,686.044 | 5,833.73 | −1.1189 | 2.09E-70 | 2.35E-69 |
| hsa-miR-1180-3p | 24.502 | 360.2708 | −3.8781 | 2.61E-57 | 2.81E-56 |
| hsa-miR-144-5p | 1,005.339 | 2,512.231 | −1.3213 | 2.63E-52 | 2.76E-51 |
| hsa-miR-484 | 313.0391 | 1,013.832 | −1.6954 | 3.10E-41 | 3.01E-40 |
| hsa-miR-22-3p | 344.6363 | 942.5566 | −1.4515 | 1.79E-26 | 1.55E-25 |
| hsa-miR-142-5p | 1,432.752 | 2,882.435 | −1.0085 | 1.41E-24 | 1.17E-23 |
| hsa-miR-185-3p | 43.04406 | 238.2566 | −2.4686 | 1.30E-21 | 1.02E-20 |
| hsa-miR-501-3p | 61.1131 | 285.2368 | −2.2226 | 1.98E-21 | 1.52E-20 |
| hsa-miR-7706 | 30.84036 | 137.3163 | −2.1546 | 1.53E-10 | 9.27E-10 |
| hsa-miR-2110 | 11.82529 | 74.63137 | −2.6579 | 1.33E-08 | 7.63E-08 |
| hsa-miR-5010-3p | 18.25825 | 79.32938 | −2.1193 | 1.68E-06 | 8.77E-06 |
| hsa-miR-4685-3p | 1.986649 | 30.73846 | −3.9516 | 2.56E-06 | 1.32E-05 |
| hsa-miR-4732-3p | 5.203128 | 41.61101 | −2.9995 | 3.37E-06 | 1.71E-05 |
| hsa-miR-1306-5p | 4.257105 | 34.49687 | −3.0185 | 2.14E-05 | 0.00010511 |
| hsa-miR-1299 | 0 | 19.59745 | −5.2926 | 3.33E-05 | 0.00015988 |
| hsa-miR-502-3p | 80.88499 | 197.9879 | −1.2915 | 3.70E-05 | 0.00017426 |
| hsa-miR-92b-3p | 19.01507 | 71.67833 | −1.9144 | 4.13E-05 | 0.00019337 |
| hsa-miR-320b | 61.86992 | 155.0346 | −1.3253 | 0.000148 | 0.00064948 |
| hsa-miR-629-5p | 174.7305 | 356.9151 | −1.0304 | 0.000173 | 0.00075186 |
| hsa-miR-7976 | 34.43525 | 98.65837 | −1.5186 | 0.000255 | 0.0010843 |
| hsa-miR-548ar-3p | 2.365058 | 21.87934 | −3.2096 | 0.000419 | 0.0016988 |
| hsa-miR-30a-3p | 3.405684 | 24.69815 | −2.8584 | 0.000545 | 0.0021671 |
| hsa-miR-4732-5p | 5.29773 | 28.59079 | −2.4321 | 0.001092 | 0.004256 |
| hsa-miR-6806-3p | 2.365058 | 19.8659 | −3.0703 | 0.001101 | 0.0042663 |
| hsa-miR-4326 | 23.08297 | 69.39643 | −1.588 | 0.001162 | 0.0044837 |
| hsa-miR-151a-5p | 55.05856 | 131.813 | −1.2595 | 0.001201 | 0.0046087 |
| hsa-miR-1294 | 7.095175 | 31.14115 | −2.1339 | 0.002526 | 0.0094649 |
| hsa-miR-550b-3p | 11.91989 | 41.87947 | −1.8129 | 0.003154 | 0.011652 |
| hsa-miR-550a-5p | 14.09575 | 44.42982 | −1.6563 | 0.006198 | 0.022071 |
| hsa-miR-550a-3-5p | 14.09575 | 44.2956 | −1.6519 | 0.006445 | 0.022846 |
| hsa-miR-4742-3p | 2.83807 | 16.91286 | −2.5751 | 0.008381 | 0.029184 |
| hsa-miR-18a-3p | 12.67671 | 39.59758 | −1.6432 | 0.010488 | 0.036044 |
| hsa-miR-3135a | 0 | 7.651057 | −4.7527 | 0.01163 | 0.039624 |