Figure 1.
Protein-protein interaction network analysis of the dysregulated genes in endometrial adenocarcinoma. The 56 significantly dysregulated genes (47 upregulated and 9 downregulated) were input into the Search Tool for the Retrieval of Interacting Genes (STRING) database for protein-protein interaction (PPI) network analysis. The minimum required interaction score was set to the medium confidence (score =0.400). Nodes represent proteins and edges represent protein-protein associations. Nodes without edges are not displayed. This analysis obtained a highly interactive PPI network of 56 nodes and 67 edges, with PPI enrichment P value of <1.0×10−16. Most genes in the PPI network were associated with three biological pathways, including defense response (19 genes, shown in blue), response to stimulus (44 genes, shown in green), and immune system process (21 genes, shown in red). From (12).