Table 1. Review of articles according to sample size, overall accuracy, observed agreement, and downgrading and upgrading based on D&C, hysteroscopic biopsy, and office endometrial biopsy.
| References | Method | Sample size | Overall accuracy (%) | Observed agreement on tumor grade and Cohen’s kappa (κ) | Downgrading (%) | Upgrading (%) | |
|---|---|---|---|---|---|---|---|
| (%) | (κ) | ||||||
| Thanachaiviwat et al. (21) | D&C | 86 | 93.0 | 70.0 | 0.5 | NS | NS |
| Kisielewski et al. (22) | 160 | 83.8 | 74.3 | 0.3 | NS | NS | |
| Tanaka et al. (23) | 378 | 87.8 | NS | 0.7* | NS | NS | |
| Göksedef et al. (24) | 335 | 64.1 | 64.0 | 0.4 | NS | 25.8 | |
| Karateke et al. (25) | 136 | 91.0 | 61.0 | 0.4 | 8.0 | 31.0 | |
| Su et al. (26) | 127 | NS | 87.4 | 0.8 | NS | 12.6 | |
| Kukovič et al., unpublished data | 134 | 82.0 | NS | 0.7 | NS | NS | |
| Lago et al. (27) | 43 | NS | 68.0 | 0.4 | NS | NS | |
| Garcia et al. (28) | 34 | 85.2 | 69.2 | 0.5 | NS | NS | |
| Mean | 159.2 | 83.8 | 70.6 | 0.5 | 8.0 | 23.1 | |
| SD | 120.2 | 9.5 | 8.6 | 0.2 | – | 9.5 | |
| Median | 134 | 85.2 | 69.2 | 0.5 | 8 | 25.6 | |
| Martinelli et al. (11) | HSC-b** | 78 | 80.2 | 64.0 | 0.6* | NS | NS |
| Ørtoft et al. (19) | 143 | 81.0 | 81.0 | 0.6 | 9.0 | 8.0 | |
| Cignini et al. (2) | 66 | NS | 94.4 | 0.9* | 8.0 | 3.4 | |
| Su et al. (26) | 76 | NS | 97.0 | 0.9 | NS | 2.6 | |
| Phelippeau et al. (12) | 75 | 80.0 | 92.0 | NS | 10.7 | 9.3 | |
| Kukovič et al., unpublished data | 66 | 81.0 | NS | 0.6 | NS | NS | |
| Lago et al. (27) | 187 | NS | 75.0 | 0.6 | NS | NS | |
| Garcia et al. (28) | 69 | 83.8 | 56.4 | 0.4 | NS | NS | |
| Mean | 95.0 | 81.2 | 85.7 | 0.7 | 9.2 | 5.8 | |
| SD | 45.0 | 1.5 | 13.6 | 0.2 | 1.4 | 3.3 | |
| Median | 75.5 | 81 | 92.0 | 0.6 | 9 | 5.7 | |
| Okadome et al. (29) | Office endometrial biopsy | 110 | 76.4 | 71.0 | 0.5 | 9.1 | 5.5 |
| Phelippeau et al. (12) | 179 | 79.2 | 93.0 | NS | 14.1 | 6.7 | |
| Kukovič et al., unpublished data | 14 | 79.0 | NS | 0.7 | NS | NS | |
| Lago et al. (27) | 102 | NS | 64.0 | 0.4 | NS | NS | |
| Garcia et al. (28) | 38 | 76.3 | 65.6 | 0.5 | NS | NS | |
| Mean | 88.6 | 77.7 | 73.4 | 0.5 | 11.6 | 6.1 | |
| SD | 65.1 | 1.6 | 13.4 | 0.1 | 3.5 | 0.8 | |
| Median | 102 | 77.7 | 68.3 | 0.5 | 11.6 | 6.1 | |
| Batista et al. (30) | D&C, HSC-b**, office endometrial biopsy | 79 | NS | 60.6 | 0.2* | NS | 15.2 |
| Garcia et al. (28) | NS | NS | NS | NS | 18.6 | 23.8 | |
| Lago et al. (27) | NS | NS | NS | NS | 11.7 | 15.9 | |
| Kukovič et al., unpublished data | NS | NS | NS | NS | 6.5 | 9.3 | |
| Mean | – | – | – | – | 12.3 | 16.1 | |
| SD | – | – | – | – | 6.1 | 6.0 | |
| Median | – | – | – | – | 11.7 | 15.6 | |
| Corr et al. (17) | D&C, office endometrial biopsy | 308 | NS | 79.2 | 0.6 | 1.1 | 6.3 |
| Cho et al. (31) | 182 | 80.8 | 81.0 | 0.7 | NS | 13.5 | |
| Talhouk et al. (32) | 47 | 75.4 | 75.0 | 0.7* | NS | NS | |
| Mean | 179.0 | 78.1 | 78.4 | 0.7 | 1.1 | 9.9 | |
| SD | 130.5 | 3.8 | 3.1 | 0.1 | – | 5.1 | |
| Median | 182 | 78.1 | 79.2 | 0.7 | 1.1 | 9.9 | |
*, articles that also reported the P value; **, hysteroscopic biopsy. NS, not stated.