Table 3. Distribution and composition ratios of mNGS detection of pathogenic microorganisms in the patients’ lung tissues and alveolar lavage fluid (%).
| Pathogenic microorganism | TBLB | BALF | |||
|---|---|---|---|---|---|
| Number of strains | Composition ratio | Number of strains | Composition ratio | ||
| Prokaryotic microorganism | 48 | 44.44 | 52 | 44.44 | |
| Actinomyces odontolyticus | 4 | 3.70 | 5 | 4.27 | |
| Enterococcus faecium | 4 | 3.70 | 2 | 1.71 | |
| Nocardia cyriacigeorgica | 2 | 1.85 | 2 | 1.71 | |
| Nocardia africana | 1 | 0.93 | 1 | 0.85 | |
| Pseudomonas aeruginosa | 8 | 7.41 | 11 | 9.40 | |
| Acinetobacter baumannii | 8 | 7.41 | 9 | 7.69 | |
| Klebsiella pneumoniae | 8 | 7.41 | 10 | 8.55 | |
| Enterobacter hormaechei | 2 | 1.85 | 2 | 1.71 | |
| Chlamydia psittaci | 1 | 0.93 | 0 | 0 | |
| Mycobacterium tuberculosis | 9 | 8.33 | 9 | 7.69 | |
| Mycobacterium kansasii | 1 | 0.93 | 1 | 0.85 | |
| Eukaryotic microorganism | 29 | 26.85 | 32 | 27.35 | |
| Pneumocystis jirovercii | 12 | 11.10 | 12 | 10.26 | |
| Cryptococcus neoformans | 3 | 2.78 | 2 | 1.71 | |
| Aspergillus oryzae | 6 | 5.56 | 5 | 4.27 | |
| Aspergillus fumigatus | 3 | 2.78 | 6 | 5.13 | |
| Aspergillus niger | 1 | 0.93 | 3 | 2.56 | |
| Aspergillus flavus | 2 | 1.85 | 2 | 1.71 | |
| Aspergillus tubingensis | 1 | 0.93 | 1 | 0.85 | |
| Rhizopus delemar | 1 | 0.93 | 1 | 0.85 | |
| Virus | 31 | 28.70 | 33 | 28.21 | |
| Human betaherpesvirus 5 | 15 | 13.89 | 18 | 15.38 | |
| Human gammaherpesvirus 4 | 8 | 7.41 | 9 | 7.69 | |
| Human alphaherpesvirus 1 | 8 | 7.41 | 6 | 5.13 | |
| Total | 108 | 100.00 | 117 | 100.00 | |
All values are indicated as the number of strains and percentage. mNGS, metagenomic next-generation sequencing; TBLB, transbronchial lung biopsy; BALF, bronchoalveolar lavage fluid.