TABLE 1.
MICs of fluconazole against 210 Candida spp. according to NCCLS macrodilution method M27-A with RPMI 1640 broth
| Species (no. of isolates)a | Geometric mean MICb (range) at:
|
|
|---|---|---|
| 24 h | 48 h | |
| C. albicans (150) | 1.99 (0.125–64) | 6.71 (0.125–128) |
| C. glabrata (18) | 5.91 (0.125–64) | 18.43 (0.125–64) |
| C. tropicalis (16) | 1.16 (0.125–4) | 4.84 (0.125–32) |
| C. guilliermondii (14) | 39.17 (0.125–64) | 68.71 (1–128) |
| C. parapsilosis (9) | 0.90 (0.125–2) | 2.07 (0.125–8) |
| C. intermedia (1) | 8 | 8 |
| C. sake (1) | 64 | 64 |
| C. utilis (1) | 0.125 | 1 |
a
Numbers of isolates for which the MIC was ≥8 μg/ml at 48 h are as follows: C. albicans, 15; C. glabrata, 8; C. tropicalis, 3; C. guilliermondii, 12; C. parapsilosis, 1; C. intermedia, 1; C. sake, 1.
b
In micrograms per milliliter.