. 2021 Dec;10(12):5246–5257. doi: 10.21037/tcr-21-1276

Table 1. Identification of DEGs between tamoxifen resistant and tamoxifen sensitive samples.

	Genes
Upregulated	PRKCA, HHLA3, PGM2L1, C8orf44-SGK3///SGK3, C6orf89, MR1, FBP1, SCYL2, CSGALNACT1, FAS, ZDHHC5, MTHFD2, SDC2, EFNA5, CEP97, ENC1, ELOVL2-AS1, EIF2AK2, LMBRD2, RERG, MAP1B, CYB5B, ARHGEF6, SH3BGRL, NUDT7, YPEL2, CLIC3, CLIC4, RHOBTB3, NEK2, USP47, TPBG, SMARCA4, P2RX4, CHRNA5, MYO1B, ZFP36L2, CAB39, POLI, C5orf24, TIA1, KCNJ8, USP42, TMEM87B, GOPC, ZGRF1, KCNK5, ACVR1C, KCTD1, FBXO38, DDX3X, GPATCH2, C12orf65, ASAH1, SQSTM1, NME7, ENTPD3, CTDSPL2, ACTA2, MIR612///NEAT1, BTN3A2, CTSO, CTNNA1, TRIM38, DGKH, SPTAN1, OSMR, NKTR, BBX, CDK13, GLUD2, TEX9, FARSA, RAB32, TMC5, KIAA0513, ONECUT2, BHLHE41, SLC1A4, SELM, MBNL1, HNRNPD, WDR90, SPAG9, LOC101928524, SETBP1, LMNB1, TMPRSS3, AGFG1, PARP9, LOC642852, TPR, GALC, VAV3, HIST1H2AM, NR2F2, CPEB4, FOXO3B///FOXO3, CYP4B1, HIST1H2AE, GADD45B, RAB5A, TRIM6-TRIM34///TRIM34, ARHGAP5, ARID1A, ID2B///ID2, SLC7A8, JUND, RBAK, MINCR, NR1D2, HLA-DQB1, AKAP1, SGMS2, IGF1R, FAM76A, PIK3R1, RECQL4, FUS, DLX2, MIA3, LOC101060835///LOC100996809///HLA-DRB5///HLA-DRB4///HLA-DRB1///HLA-DQB1, CAPN8, FAM117A, FDFT1, F11R, ZNF431, MT1F, NUP210, ASAP1, TM7SF2, SP110, SDC1, SYTL2, TFPI, ST8SIA4, SALL4, SNX27, GALNT2, CDKL5, KIF5C, DCAF16, SNORA28///EIF5, GNB4, FREM2, LGALS3BP, ABCD3, ZNF850, EXPH5, EHD1, TMX1, ATP6V1A, LIPA, GBP2, MAP2, DGKA, OGDH, ADGRL2, TRIO, STIP1, NFIB, MAP3K1, PCDH19, PMEPA1, FAM213A, MAN1A1, AMOTL1, HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I, C1orf115, TIAM1, FNIP1, ZYX, RBM22, GATC, CLCC1, HSPA2, U2SURP, SP100, LOC100288911, MVD, GDPD1, MAVS, SMTN, PHF10, C17orf80, EDEM3, LYST, PPP2R3B, SLC24A3, PAPOLA, ADCY1, RANBP2, DACH1, TFPI2, BCAT1, HDAC8, ZNF253, MYCBP2, TRIM59///IFT80, GGCX, PGGT1B, HMGN5, ANXA9, SLC22A15, LOC101929597///TBCD, HIPK1, KPNA1, NBPF1, CFL1, GSAP, WTAP, TPP1, GBP3, MYEF2, DENND4C, FNIP2, SCUBE2, KRIT1, CCDC83, GULP1, 6-Mar, SUGT1, FYTTD1, CLDN3, NDRG1, STX17, EFNB2, C21orf91, KDM4B, C14orf132, ATXN1, CENPF, MSMO1, LY6E, ACYP1, AKAP13, ERVMER34-1, AGA, ANLN, EIF5A2, GOSR2, KLHL20, ANOS1, RBM48, R3HCC1L, STC2, CITED1, GGT6, SECISBP2L, NDST4, EXOC6, RUNDC1, USP10, JPX, USP34, BTN3A2///BTN3A3, GEM, SRSF4, SLC4A7, BBS9, ITGB4, XPO7, AGR2, TANK, IRF7, CITED2, CACNG4, CYP1B1, PRNP, NR3C1, KRT15, SERPINI1, MAPK1IP1L, PHF23, CEBPG, GRN, ZMYM2, METTL8, CA5BP1, DNMT3A, TANC2, MPPED2, HERPUD2, PABPN1, TBL1X, TMEFF2, TBRG1, RAB30, ZNF711, SEC61A1, LAMP1, SYNRG, BRINP3, ZYG11B, MBTPS1, SRRT, ZNRF2, SEPHS1, FBXW11, PHLDA1
Downregulated	SHANK2, CPSF6, MOCS3, C1GALT1, TOB2, WBSCR22, AP1S3, WLS, METTL4, DEGS1, MED30, MAPKAP1, HLA-A, RBM26, NCOA3, SLC39A6, SLC9A7, CD163L1, EPHA4, GFPT1, SNORD3D///SNORD3C///SNORD3B-2///SNORD3A///SNORD3B-1, BFSP1, KIF3A, TFRC, PRKAB1, ARHGEF28, UBE2J1, PLA2G16, ZNF652, SLC18B1, IFNGR1, CCDC88C, RAD52, FARSB, CAPRIN1, FRMD5, CSNK1A1, MIR1908///FADS1, MRPL30, SETD5, SCPEP1, TIMP2, FAM83A, ATP1B1, LZTFL1, ZNF236, LOC101060835///HLA-DQB1, COL12A1, CA8, LINC00839, CHTF18, GPX3, PSME4, MBP, GPR87, HIST1H4H, PM20D2, SERPINA1, PSEN1, KIFAP3, SYTL4, FGFR2, ERAP1, SGK1, LSS, SOX2, FSIP1, TM9SF1, PCYOX1, TFF1, IRF9, ARFIP1, ZFP90, RAP2A, RBMS1, LARP4, LOC101930578///TPTE2P2, RAMP1, ESR1, MPZL2, KBTBD2, ZNFX1, ELL2, SEPT2, SLC44A1, S100A4, EPC1, MYB, COBLL1, HHIPL2, B4GALT1, HSPA4, FLVCR2, SLC12A6, CA12, LOC100505984///ITGB6, SCN1B, JPH1, LNPEP, SOWAHC, KCTD6, PPM1E, PAPSS2, ATP10D, CDC14B, TBC1D3P1-DHX40P1///RNFT1, PJA1, ZNF703, JMY, MAPK1, FAM189A2, SHMT2, CD59, ARSG, HIST1H2BD, MIR4784///MZT2A///MZT2B, MGP, DLC1, STK38, CPNE4, SOX3, C1orf226, SPANXA2///SPANXA1, TMEM192, HOOK3, CXCL12, PGR, PIK3R3, MALRD1, SMAD5, WWP1, IL20, GBP1, ELOVL2, GFRA1, PLXDC2, GREB1, FCMR

Genes

Upregulated

PRKCA, HHLA3, PGM2L1, C8orf44-SGK3///SGK3, C6orf89, MR1, FBP1, SCYL2, CSGALNACT1, FAS, ZDHHC5, MTHFD2, SDC2, EFNA5, CEP97, ENC1, ELOVL2-AS1, EIF2AK2, LMBRD2, RERG, MAP1B, CYB5B, ARHGEF6, SH3BGRL, NUDT7, YPEL2, CLIC3, CLIC4, RHOBTB3, NEK2, USP47, TPBG, SMARCA4, P2RX4, CHRNA5, MYO1B, ZFP36L2, CAB39, POLI, C5orf24, TIA1, KCNJ8, USP42, TMEM87B, GOPC, ZGRF1, KCNK5, ACVR1C, KCTD1, FBXO38, DDX3X, GPATCH2, C12orf65, ASAH1, SQSTM1, NME7, ENTPD3, CTDSPL2, ACTA2, MIR612///NEAT1, BTN3A2, CTSO, CTNNA1, TRIM38, DGKH, SPTAN1, OSMR, NKTR, BBX, CDK13, GLUD2, TEX9, FARSA, RAB32, TMC5, KIAA0513, ONECUT2, BHLHE41, SLC1A4, SELM, MBNL1, HNRNPD, WDR90, SPAG9, LOC101928524, SETBP1, LMNB1, TMPRSS3, AGFG1, PARP9, LOC642852, TPR, GALC, VAV3, HIST1H2AM, NR2F2, CPEB4, FOXO3B///FOXO3, CYP4B1, HIST1H2AE, GADD45B, RAB5A, TRIM6-TRIM34///TRIM34, ARHGAP5, ARID1A, ID2B///ID2, SLC7A8, JUND, RBAK, MINCR, NR1D2, HLA-DQB1, AKAP1, SGMS2, IGF1R, FAM76A, PIK3R1, RECQL4, FUS, DLX2, MIA3, LOC101060835///LOC100996809///HLA-DRB5///HLA-DRB4///HLA-DRB1///HLA-DQB1, CAPN8, FAM117A, FDFT1, F11R, ZNF431, MT1F, NUP210, ASAP1, TM7SF2, SP110, SDC1, SYTL2, TFPI, ST8SIA4, SALL4, SNX27, GALNT2, CDKL5, KIF5C, DCAF16, SNORA28///EIF5, GNB4, FREM2, LGALS3BP, ABCD3, ZNF850, EXPH5, EHD1, TMX1, ATP6V1A, LIPA, GBP2, MAP2, DGKA, OGDH, ADGRL2, TRIO, STIP1, NFIB, MAP3K1, PCDH19, PMEPA1, FAM213A, MAN1A1, AMOTL1, HIST2H4B///HIST4H4///HIST2H4A///HIST1H4L///HIST1H4E///HIST1H4B///HIST1H4H///HIST1H4C///HIST1H4J///HIST1H4K///HIST1H4F///HIST1H4D///HIST1H4A///HIST1H4I, C1orf115, TIAM1, FNIP1, ZYX, RBM22, GATC, CLCC1, HSPA2, U2SURP, SP100, LOC100288911, MVD, GDPD1, MAVS, SMTN, PHF10, C17orf80, EDEM3, LYST, PPP2R3B, SLC24A3, PAPOLA, ADCY1, RANBP2, DACH1, TFPI2, BCAT1, HDAC8, ZNF253, MYCBP2, TRIM59///IFT80, GGCX, PGGT1B, HMGN5, ANXA9, SLC22A15, LOC101929597///TBCD, HIPK1, KPNA1, NBPF1, CFL1, GSAP, WTAP, TPP1, GBP3, MYEF2, DENND4C, FNIP2, SCUBE2, KRIT1, CCDC83, GULP1, 6-Mar, SUGT1, FYTTD1, CLDN3, NDRG1, STX17, EFNB2, C21orf91, KDM4B, C14orf132, ATXN1, CENPF, MSMO1, LY6E, ACYP1, AKAP13, ERVMER34-1, AGA, ANLN, EIF5A2, GOSR2, KLHL20, ANOS1, RBM48, R3HCC1L, STC2, CITED1, GGT6, SECISBP2L, NDST4, EXOC6, RUNDC1, USP10, JPX, USP34, BTN3A2///BTN3A3, GEM, SRSF4, SLC4A7, BBS9, ITGB4, XPO7, AGR2, TANK, IRF7, CITED2, CACNG4, CYP1B1, PRNP, NR3C1, KRT15, SERPINI1, MAPK1IP1L, PHF23, CEBPG, GRN, ZMYM2, METTL8, CA5BP1, DNMT3A, TANC2, MPPED2, HERPUD2, PABPN1, TBL1X, TMEFF2, TBRG1, RAB30, ZNF711, SEC61A1, LAMP1, SYNRG, BRINP3, ZYG11B, MBTPS1, SRRT, ZNRF2, SEPHS1, FBXW11, PHLDA1

Downregulated

SHANK2, CPSF6, MOCS3, C1GALT1, TOB2, WBSCR22, AP1S3, WLS, METTL4, DEGS1, MED30, MAPKAP1, HLA-A, RBM26, NCOA3, SLC39A6, SLC9A7, CD163L1, EPHA4, GFPT1, SNORD3D///SNORD3C///SNORD3B-2///SNORD3A///SNORD3B-1, BFSP1, KIF3A, TFRC, PRKAB1, ARHGEF28, UBE2J1, PLA2G16, ZNF652, SLC18B1, IFNGR1, CCDC88C, RAD52, FARSB, CAPRIN1, FRMD5, CSNK1A1, MIR1908///FADS1, MRPL30, SETD5, SCPEP1, TIMP2, FAM83A, ATP1B1, LZTFL1, ZNF236, LOC101060835///HLA-DQB1, COL12A1, CA8, LINC00839, CHTF18, GPX3, PSME4, MBP, GPR87, HIST1H4H, PM20D2, SERPINA1, PSEN1, KIFAP3, SYTL4, FGFR2, ERAP1, SGK1, LSS, SOX2, FSIP1, TM9SF1, PCYOX1, TFF1, IRF9, ARFIP1, ZFP90, RAP2A, RBMS1, LARP4, LOC101930578///TPTE2P2, RAMP1, ESR1, MPZL2, KBTBD2, ZNFX1, ELL2, SEPT2, SLC44A1, S100A4, EPC1, MYB, COBLL1, HHIPL2, B4GALT1, HSPA4, FLVCR2, SLC12A6, CA12, LOC100505984///ITGB6, SCN1B, JPH1, LNPEP, SOWAHC, KCTD6, PPM1E, PAPSS2, ATP10D, CDC14B, TBC1D3P1-DHX40P1///RNFT1, PJA1, ZNF703, JMY, MAPK1, FAM189A2, SHMT2, CD59, ARSG, HIST1H2BD, MIR4784///MZT2A///MZT2B, MGP, DLC1, STK38, CPNE4, SOX3, C1orf226, SPANXA2///SPANXA1, TMEM192, HOOK3, CXCL12, PGR, PIK3R3, MALRD1, SMAD5, WWP1, IL20, GBP1, ELOVL2, GFRA1, PLXDC2, GREB1, FCMR

438 DEGs indentified between tamoxifen resistant and tamoxifen sensitive samples are listed, of which 300 upregulated and 138 downregulated. DEGs, differentially expressed genes.