Table 2. GO and pathway enrichment analyses for DEGs.
| Category | Term | Count | P value |
|---|---|---|---|
| Upregulated DEGs | |||
| GOTERM_CC_DIRECT | GO:0005737-cytoplasm | 98 | 4.79×10−3 |
| GOTERM_CC_DIRECT | GO:0005829-cytosol | 69 | 2.19×10−3 |
| GOTERM_CC_DIRECT | GO:0016020-membrane | 54 | 2.05×10−4 |
| GOTERM_CC_DIRECT | GO:0048471-perinuclear region of cytoplasm | 19 | 5.18×10−3 |
| GOTERM_CC_DIRECT | GO:0043231-intracellular membrane-bounded organelle | 17 | 8.95×10−3 |
| GOTERM_MF_DIRECT | GO:0005515-protein binding | 159 | 1.69×10−3 |
| GOTERM_MF_DIRECT | GO:0005524-ATP binding | 34 | 2.04×10−2 |
| GOTERM_MF_DIRECT | GO:0044822-poly(A) RNA binding | 26 | 3.98×10−2 |
| GOTERM_MF_DIRECT | GO:0000166-nucleotide binding | 13 | 7.41×10−3 |
| GOTERM_MF_DIRECT | GO:0008134-transcription factor binding | 11 | 1.22×10−2 |
| GOTERM_BP_DIRECT | GO:0000122-negative regulation of transcription from RNA polymerase II promoter | 20 | 1.45×10−2 |
| GOTERM_BP_DIRECT | GO:0045892-negative regulation of transcription, DNA-templated | 15 | 2.12×10−2 |
| GOTERM_BP_DIRECT | GO:0015031-protein transport | 12 | 4.04×10−2 |
| GOTERM_BP_DIRECT | GO:0007399-nervous system development | 10 | 3.23×10−2 |
| GOTERM_BP_DIRECT | GO:0051260-protein homooligomerization | 8 | 1.89×10−2 |
| KEGG_PATHWAY | hsa05164:Influenza A | 11 | 6.44×10−4 |
| KEGG_PATHWAY | hsa05161:Hepatitis B | 7 | 3.48×10−2 |
| KEGG_PATHWAY | hsa04670:Leukocyte transendothelial migration | 7 | 1.41×10−2 |
| KEGG_PATHWAY | hsa04142:Lysosome | 7 | 1.58×10−2 |
| KEGG_PATHWAY | hsa04622:RIG-I-like receptor signaling pathway | 5 | 2.96×10−2 |
| Downregulated DEGs | |||
| GOTERM_CC_DIRECT | GO:0005886-plasma membrane | 37 | 4.59×10−2 |
| GOTERM_CC_DIRECT | GO:0070062-extracellular exosome | 36 | 1.36×10−4 |
| GOTERM_CC_DIRECT | GO:0005829-cytosol | 31 | 4.64×10−2 |
| GOTERM_CC_DIRECT | GO:0005654-nucleoplasm | 28 | 2.77×10−2 |
| GOTERM_CC_DIRECT | GO:0016020-membrane | 25 | 1.04×10−2 |
| GOTERM_MF_DIRECT | GO:0005515-protein binding | 80 | 1.03×10−3 |
| GOTERM_MF_DIRECT | GO:0005524-ATP binding | 15 | 1.67×10−2 |
| GOTERM_MF_DIRECT | GO:0042802-identical protein binding | 12 | 1.67×10−2 |
| GOTERM_MF_DIRECT | GO:0016301-kinase activity | 5 | 9.09×10−3 |
| GOTERM_MF_DIRECT | GO:0098641-cadherin binding involved in cell-cell adhesion | 4 | 3.35×10−2 |
| GOTERM_BP_DIRECT | GO:0045893-positive regulation of transcription, DNA-templated | 10 | 1.10×10−2 |
| GOTERM_BP_DIRECT | GO:0060333-interferon-gamma-mediated signaling pathway | 4 | 1.39×10−2 |
| GOTERM_BP_DIRECT | GO:0006730-one-carbon metabolic process | 3 | 1.90×10−2 |
| GOTERM_BP_DIRECT | GO:0071392-cellular response to estradiol stimulus | 3 | 2.03×10−2 |
| GOTERM_BP_DIRECT | GO:0060348-bone development | 3 | 3.57×10−2 |
| KEGG_PATHWAY | hsa04919:Thyroid hormone signaling pathway | 6 | 2.56×10−3 |
| KEGG_PATHWAY | hsa05203:Viral carcinogenesis | 6 | 2.81×10−2 |
| KEGG_PATHWAY | hsa04550:Signaling pathways regulating pluripotency of stem cells | 5 | 2.95×10−2 |
| KEGG_PATHWAY | hsa04960:Aldosterone-regulated sodium reabsorption | 4 | 4.14×10−3 |
| KEGG_PATHWAY | hsa04066:HIF-1 signaling pathway | 4 | 4.87×10−2 |
Top five GO terms in diversetables and major pathways are listed. Count, number of DEGs; GO,gene ontology; DEGs, differentially expressed genes; MF, molecular function; BP, biological process; CC, cellular component; KEGG, KyotoEncyclopedia of Genes and Genomes.