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. 2020 Apr;9(4):2378–2389. doi: 10.21037/tcr.2020.03.49

Table 2. Analysis for the optimal cutoff point of CRP, ferritin, LDH, and cytokines in serum.

Variable AUC 95% CI P value Cutoff value Sensibility Specificity
LDH 0.688 0.561–0.816 0.001 548 U/L 0.462 0.968
CRP 0.754 0.637–0.871 0.001 25.35 µg/L 0.462 0.962
Ferritin 0.707 0.578–0.835 0.005 323.25 mg/L 0.795 0.577
IL-2 0.552 0.408–0.696 0.487
IL-4 0.570 0.429–0.711 0.346
IL-6 0.833 0.728–0.937 <0.001 15.920 pg/mL 0.641 0.920
IL-10 0.769 0.651–0.888 <0.001 6.145 pg/mL 0.692 0.800
IL-17A 0.481 0.339–0.622 0.794
TNF-α 0.728 0.604–0.852 0.002 0.275 pg/mL 0.846 0.520
IFN-γ 0.588 0.446–0.729 0.239

LDH, lactate dehydrogenase; CRP, C-reactive protein; IL, interleukin; TNF-α, tumor necrosis factor-α; IFN-γ, interferon-γ.