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| Favorable risk | Intermediate/poor risk |
|---|---|
| High dose interleukin 2 [1992] | High dose interleukin 2 [1992] |
| Sunitinib [2006] | Sunitinib [2006] |
| Bevacizumab + interferon alfa [2009] | Temsirolimus [2007] |
| Pazopanib [2009] | Bevacizumab + interferon alfa [2009] |
| Axitinib + pembrolizumab [2019] | Pazopanib [2009] |
| Axitinib + avelumab [2019] | Carbozantinib [2016] |
| Ipilimumab + nivolumab [2018] | |
| Axitinib + pembrolizumab [2019] | |
| Axitinib + avelumab [2019] |
