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. 2019 Aug;8(4):1550–1559. doi: 10.21037/tcr.2019.08.07

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Comparative analysis of serum exosomes from HCC and healthy individuals. (A) Transmission electron micrographs of blood serum exosomes derived from HCC patients and healthy individuals; (B) immunoblotting of CD63, CD9, flotillin-1 and β-actin in exosomes and Huh-7 cells; (C) nanoparticle tracking analysis of serum exosomes from HCC isolated by total exosome isolation reagent precipitation; (D) increased concentration of serum exosomes was observed in HCC (n=48) when compared with the healthy individuals (n=9). *P<0.05, as indicated. HCC, hepatocellular carcinoma; CD, cluster of differentiation.