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. 2019 Aug;8(4):1550–1559. doi: 10.21037/tcr.2019.08.07

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2019 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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HCC exosomes promote xenograft tumor growth and angiogenesis. (A) Representative examples of mice treated with different types of exosomes. (B) The mice weight overtime. (C) Tumor growth over time. (D and E) Tumors were analyzed by immunohistochemistry analysis for CD31 expression and vascular density (scale bar, 100 µm). **P<0.01. HCC, hepatocellular carcinoma; HCC-ex, exosomes derived from HCC patients; normal-ex, exosomes derived from healthy individuals; CD, cluster of differentiation.