Table S2. Demographic and clinical characteristics of the 48 HCC patients enrolled in the study.

Variable	Sample	Age (y)	Sex (0: male; 1: female)	Tumor size (0: ≤5 cm; 1: >5 cm)	BCLC stage (1: A; 2: B; 3: C stage)	Venous invasion (0: none; 1: presence)	Serum exosome concentration (µg/μL)	Serum HIF-1ɑ levels in exosomes (pg/mL)
Cohort of serum exosome concentration	01	63	0	0	3	1	4.43945	350.184
	02	47	1	0	2	0	9.516948	265.127
	03	42	1	0	2	0	5.372052	264.266
	04	59	0	1	2	0	2.846256	218.626
	05	87	0	0	2	0	4.931657	298.5
	06	59	0	0	2	0	2.308715	271.378
	07	57	0	0	2	0	11.49225	294.68
	08	69	0	1	3	1	2.949878	255.244
	09	55	1	0	3	0	5.410911	452.049
	10	61	0	1	3	1	3.183029	362.828
	11	36	0	1	3	1	3.732407	389.292
	12	58	0	0	3	0	2.682166	444.908
	13	30	0	1	3	0	2.871905	328.89
	14	41	0	1	2	0	2.475503	354.431
	15	31	0	0	2	0	2.184215	254.555
	16	51	0	1	3	1	2.868341	397.25
	17	84	0	1	2	0	2.442544	377.628
	18	79	0	0	2	0	4.343488	416.774
	19	42	0	1	2	0	7.406912	400.933
	20	33	0	1	2	0	4.88687	422.935
	21	47	1	0	3	1	4.193836	233.529
	22	84	1	1	3	1	3.177445	234.68
	23	32	1	1	3	1	5.155888	500.594
	24	53	0	1	3	0	3.727062	495.199
	25	33	0	0	2	0	4.233921	541.786
	26	61	0	0	2	0	6.370034	212.567
	27	29	0	1	2	0	4.714056	497.536
	28	48	1	0	2	0	3.639765	188.795
	29	80	0	1	2	0	3.140923	208.941
	30	82	0	0	2	0	2.013184	329.68
	31	50	0	1	3	1	5.939783	239.554
	32	76	0	1	2	0	4.689115	213.839
	33	69	1	0	2	0	2.796187	251.566
Cohort of serum HIF-1ɑ levels in exosomes	34	38	0	0	2	0	3.734189	–
	35	65	1	1	2	0	7.545876	–
	36	60	1	0	3	1	1.634598	–
	37	61	0	1	2	0	3.268306	–
	38	44	0	1	2	0	3.062533	–
	39	51	1	0	3	0	7.126314	–
	40	58	0	1	3	1	8.434883	–
	41	60	0	1	2	0	4.258863	–
	42	58	0	1	2	0	4.032603	–
	43	47	0	0	2	0	5.198646	–
	44	41	0	1	3	1	11.68894	–
	45	64	1	0	2	0	3.748441	–
	46	59	0	0	3	0	2.839836	–
	47	49	0	0	3	1	2.637627	–
	48	52	0	1	2	0	5.447176	–

HCC, hepatocellular carcinoma; HIF, hypoxia-inducible factor; BCLC, Barcelona Clinic Liver Cancer.